Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

There Is No "Stem Cell Mess".

Arnold I Caplan1

  • 1Department of Biology, Skeletal Research Center, Case Western Reserve University, Cleveland, Ohio.

Tissue Engineering. Part B, Reviews
|March 20, 2019
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Culture Expansion Alters Human Bone Marrow-Derived Mesenchymal Stem Cell Production of Osteoarthritis-Relevant Cytokines and Growth Factors.

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association·2024
Same author

Multidisciplinary Management Strategies for Long COVID: A Narrative Review.

Cureus·2024
Same author

Amino Acid Uptake Limitations during Human Mesenchymal Stem Cell-Based Chondrogenesis.

Tissue engineering. Part A·2024
Same author

MSCs mediate long-term efficacy in a Crohn's disease model by sustained anti-inflammatory macrophage programming via efferocytosis.

NPJ Regenerative medicine·2024
Same author

The U.S. Food and Drug Administration, the mechanism of action, and other considerations for cell-based therapy candidates.

Experimental biology and medicine (Maywood, N.J.)·2023
Same author

Mesenchymal stem cells ameliorate inflammation in an experimental model of Crohn's disease via the mesentery.

bioRxiv : the preprint server for biology·2023
Same journal

Photobiomodulation Targets Mitochondrial Homeostasis for Diabetic Wound Healing.

Tissue engineering. Part B, Reviews·2026
Same journal

Nanotechnology-Driven Noninvasive and Targeted Therapies for Anaplastic Thyroid Carcinoma.

Tissue engineering. Part B, Reviews·2026
Same journal

From Restoration to Regeneration: A Review of 3D Printing Strategies in Digital Dentistry.

Tissue engineering. Part B, Reviews·2026
Same journal

Molecular Pathogenesis of and Regenerative Strategies for Osteonecrosis of the Femoral Head.

Tissue engineering. Part B, Reviews·2026
Same journal

Regenerative Potential of Platelet-Rich Plasma-Loaded Scaffolds in Endometrial Damage: A Meta-Analysis.

Tissue engineering. Part B, Reviews·2026
Same journal

Enhancing Round Window Membrane Permeability for Inner Ear Drug Delivery: A Systematic Review.

Tissue engineering. Part B, Reviews·2026
See all related articles

Mesenchymal stem cell therapy shows promise for treating various conditions. Further research and clinical trials are essential to fully understand its therapeutic potential.

Area of Science:

  • Regenerative Medicine
  • Cellular Therapy

Background:

  • Mesenchymal stem cells (MSCs) are multipotent stromal cells with immunomodulatory and regenerative properties.
  • Their therapeutic potential is being explored for a wide range of diseases.

Purpose of the Study:

  • To evaluate the efficacy and safety of mesenchymal stem cell-based interventions.
  • To identify key areas for future research and clinical development.

Main Methods:

  • Review of preclinical studies and clinical trial data on MSC applications.
  • Analysis of MSC mechanisms of action, including paracrine signaling and immunomodulation.

Main Results:

  • Evidence suggests MSCs can ameliorate disease progression in various models.
Keywords:
adult stem cellsmedicinal signaling cellsmesenchymal stem cellsregeneration capacity

Related Experiment Videos

  • Clinical outcomes indicate potential benefits, but variability exists across studies.

    • Conclusions:

    • Mesenchymal stem cell therapy holds significant promise for diverse clinical applications.
    • Continued rigorous research and well-designed clinical trials are crucial for advancing MSC-based treatments.