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Kikuchi-Fujimoto Disease and Prognostic Implications.

Sebastian Salamat1, Jacquline Chan2, Karan Jolly1

  • 1Department of Otolaryngology, Princess Royal Hospital, Telford, Shropshire, UK.

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|March 20, 2019
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Summary

Kikuchi-Fujimoto disease (KFD) is a rare cause of lymphadenitis. Early diagnosis and long-term follow-up are recommended due to its association with systemic lupus erythematosus (SLE).

Keywords:
Histiocytic necrotising lymphadenitisKikuchi–Fujimoto diseaseLymph nodeLymphadenopathy

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Area of Science:

  • Rheumatology
  • Pathology
  • Immunology

Background:

  • Kikuchi-Fujimoto disease (KFD) is a rare, benign, and self-limiting condition characterized by lymphadenitis.
  • First described in 1972, KFD primarily affects Asian populations and presents with lymphadenopathy, fever, fatigue, and leukopenia.

Observation:

  • A case of a 38-year-old woman with a 6-week history of cervical lymphadenopathy is presented.
  • Initial diagnostic methods including ultrasound and fine needle aspiration cytology were inconclusive.
  • Excisional lymph node biopsy confirmed the diagnosis of KFD.

Findings:

  • The etiology of KFD remains unknown, but a significant association with systemic lupus erythematosus (SLE) has been observed.
  • Studies indicate that 9% of European and 28% of East Asian KFD patients have concomitant SLE.

Implications:

  • KFD is a rare cause of cervical lymphadenopathy with potential links to SLE.
  • The findings underscore the importance of early diagnosis and sustained follow-up for KFD patients to monitor for SLE development.