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Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
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Ageing and Cognition.
Sydney M A Juan1, Paul A Adlard2
1The Florey Institute of Neuroscience and Mental Health and The University of Melbourne, Parkville, 3052, VIC, Australia.
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|March 20, 2019
Summary
As the population ages, understanding neurological changes is crucial. Research suggests zinc homeostasis may be key to preventing age-related cognitive decline and promoting healthy brain aging.
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Area of Science:
- Neuroscience
- Gerontology
- Biochemistry
Background:
- The global population is aging, with the U.S. elderly population projected to double by 2050.
- Age is the primary risk factor for neurodegenerative diseases like Alzheimer's disease.
- Age-related cognitive decline (ARCD) affects a significant portion of the elderly population, independent of dementia.
Purpose of the Study:
- To explore the concept of ARCD and its underlying mechanisms.
- To identify key neurochemical pathways involved in cognitive decline during normal aging.
- To investigate the role of zinc homeostasis in learning, memory, and ARCD.
Main Methods:
- Literature review and synthesis of existing research on aging, cognitive decline, and neurochemistry.
- Analysis of evidence implicating zinc homeostasis in cognitive function.
- Exploration of potential therapeutic targets for promoting healthy brain aging.
Main Results:
- Age-related cognitive decline is a distinct condition with a high incidence in the elderly.
- There is a significant overlap between the pathologies of healthy and pathological aging.
- Emerging evidence points to zinc homeostasis as a critical factor in learning, memory, and ARCD.
Conclusions:
- Understanding the mechanisms of ARCD is essential for promoting successful brain aging.
- Targeting neurochemical pathways, particularly those involving zinc, offers potential for therapeutic interventions.
- Further research into zinc homeostasis could lead to novel treatments for cognitive decline in aging populations.