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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Sensory Functions of the Skin01:16

Sensory Functions of the Skin

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The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Murine Full-thickness Skin Transplantation
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Skin Changes During Ageing.

Frédéric Bonté1, Dorothée Girard2,3, Jean-Christophe Archambault1

  • 1LVMH Recherche, Saint Jean de Braye, France.

Sub-Cellular Biochemistry
|March 20, 2019
PubMed
Summary
This summary is machine-generated.

Aging degrades skin structure and repair capacity, accelerating with environmental and health factors. Interventions targeting skin health, nutrition, and protection can mitigate aging effects and improve wound healing in older adults.

Keywords:
Extracellular matrixMicrobiotaMyofibroblastOestrogenPollutionReactive oxygen speciesWound healing

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Area of Science:

  • Dermatology
  • Gerontology
  • Cellular Biology

Background:

  • Skin aging involves cellular senescence and extracellular matrix damage, impairing skin function and repair.
  • Extrinsic factors (UV, pollution) and intrinsic factors (diabetes, vascular disease) accelerate skin aging.
  • Age-related skin degradation is linked to chronic wounds in the elderly, with reactive oxygen species playing a key role.

Purpose of the Study:

  • To explore mechanisms of age-induced skin degradation.
  • To identify factors contributing to impaired wound healing in the elderly.
  • To discuss potential interventions for mitigating skin aging and improving wound repair.

Main Methods:

  • Review of cellular and molecular mechanisms of skin aging.
  • Analysis of the impact of extrinsic and intrinsic factors on skin health.
  • Evaluation of therapeutic strategies for age-related skin conditions.

Main Results:

  • Cellular senescence and matrix degradation are central to skin aging.
  • Reactive oxygen species significantly contribute to age-related skin changes.
  • Hormonal status, surface nutrition, and protective skincare influence skin aging and healing.

Conclusions:

  • Targeting hormonal status and skin surface nutrition can slow skin aging.
  • Preventing radiation/pollution damage and supporting skin microbiota are crucial.
  • Interventions can minimize aging effects on skin and enhance wound healing in the elderly.