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Updated: Jan 27, 2026

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
Published on: September 18, 2014
Bubble-Propelled Jellyfish-like Micromotors for DNA Sensing
Xueqing Zhang1, Chengtao Chen1, Jie Wu1
1State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering , Nanjing University , Nanjing 210023 , P. R. China.
Abstract:
A chemically powered jellyfish-like micromotor was proposed by using a multimetallic shell and a DNA assembly with catalase decorations modified on the concave surface to simulate the umbrella-shaped body and the muscle fibers on the inner umbrella of jellyfish. Relying on the catalytic generation of oxygen gas by catalase in H2O2 fuel, the jellyfish-like micromotor showed good bubble-propelled motion in different biomedia with speed exceeding 209 μm s-1 in 1.5% H2O2. The jellyfish-like micromotors could also be applied for motion detection of DNA based on a displacement hybridization-triggered catalase release. The proposed jellyfish-like micromotors showed advantages of easy fabrication, good motion ability, sensitive motion detection of DNA, and good stability and reproducibility, indicating considerable promise for biological application.
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