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Updated: Jan 27, 2026

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
Published on: September 18, 2014
Bubble-Propelled Jellyfish-like Micromotors for DNA Sensing
Xueqing Zhang1, Chengtao Chen1, Jie Wu1
1State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering , Nanjing University , Nanjing 210023 , P. R. China.
Chemically powered, jellyfish-like micromotors were developed using DNA and catalase for bubble propulsion. These micromotors demonstrate efficient DNA motion detection, showing promise for biological applications.
Area of Science:
- Biomimetic nanotechnology
- Chemical propulsion systems
- DNA nanotechnology
Background:
- Jellyfish exhibit unique propulsion mechanisms.
- Micromotors offer potential for targeted delivery and sensing in biological systems.
- Catalase enzyme facilitates oxygen generation for propulsion.
Purpose of the Study:
- To design and fabricate jellyfish-like micromotors.
- To investigate their propulsion capabilities in biomedia.
- To explore their application in DNA detection.
Main Methods:
- Fabrication of multimetallic micromotors with DNA assembly and catalase decoration.
- Observation of bubble-propelled motion in hydrogen peroxide (H2O2) fuel.
- Utilizing displacement hybridization for DNA detection via catalase release.
Main Results:
- Achieved bubble-propelled motion exceeding 209 μm s-1 in 1.5% H2O2.
- Demonstrated successful motion detection of DNA.
- Micromotors exhibited ease of fabrication, good motion, stability, and reproducibility.
Conclusions:
- The proposed jellyfish-like micromotors are efficient and versatile.
- They hold significant potential for various biological applications, including sensing.
- The design offers a promising platform for advanced nanomachinery.
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