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Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis
06:09

Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis

Published on: July 18, 2017

Alterations of urinary carbon dioxide tension, electrolyte handling and low molecular weight protein excretion in

T Tulassay, M Miltényi, M Dobos

    Acta Paediatrica Scandinavica
    |May 1, 1986
    PubMed

    Insights

    Acute pyelonephritis in children impairs kidney function, causing reduced hydrogen ion secretion and abnormal handling of sodium and phosphate. This indicates both proximal and distal tubular dysfunction during infection.

    Area of Science:

    • Pediatric Nephrology
    • Infectious Diseases
    • Renal Physiology

    Background:

    • Urinary tract infections (UTIs) are common in children.
    • Renal tubular dysfunction can occur secondary to UTIs.

    Purpose of the Study:

    • To investigate renal tubular function in children with upper and lower UTIs.
    • To assess proximal and distal tubular function during acute pyelonephritis.

    Main Methods:

    • Performed renal tubular function tests in 45 children with UTIs.
    • Measured urinary carbon dioxide tension (PCO2) in alkaline urine to assess distal tubular H+-ion secretion.
    • Assessed urinary protein excretion, sodium handling, and phosphate reabsorption.

    Main Results:

    • Children with acute pyelonephritis showed significantly lower urinary PCO2 compared to healthy children or those with cystitis.
    • Elevated fractional excretion of sodium and decreased phosphate reabsorption were observed in acute pyelonephritis.
    • Increased urinary excretion of low molecular weight proteins was noted in pyelonephritis.

    Conclusions:

    • Acute bacterial pyelonephritis in children is associated with impaired distal tubular H+-ion secretion.
    • Evidence of both proximal and distal tubular dysfunction exists at the onset of acute pyelonephritis.
    • Renal function monitoring is crucial in children with pyelonephritis.

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