Related Experiment Video
Updated: Jan 27, 2026
Accuracy in Dental Medicine, A New Way to Measure Trueness and Precision
Published on: April 29, 2014
Accuracy and Precision of the SynchroMed II Pump
Reza Farid1, Kirstin Binz1, Jane Anne Emerson1
1Department of Physical Medicine and Rehabilitation, University of Missouri, Columbia, MO, USA.
Objective:
The objective of this study was to evaluate the accuracy and precision of SynchroMed II programmable infusion pumps for delivery of intrathecal baclofen to treat severe spasticity.
Design:
Retrospective chart review study.
Setting:
Urban academic rehabilitation clinic.
Patients (Or Participants):
Patients with spasticity treated with intrathecal baclofen.
Methods Or Interventions (Or Assessment Of Risk Factors):
A retrospective chart review of 149 patients inclusive of 755 individual patient encounters more than a 2.5-year span for baclofen pump refills was performed.
Main Outcome Measurements:
Charts were reviewed to obtain data on the concentration and dose of intrathecal baclofen, aspirated and residual volumes, age of the pump, and reservoir volume of the pump. Flow rate (mL/day) was calculated for each chronological visit. Flow rates from clinical data were used to calculate the accuracy and precision based on the manufacturer's specifications for both the 20 mL and 40 mL pumps.
Results:
The infused volume accuracy and precision of both the 20 mL pumps and 40 mL pumps remained within manufacturer's specifications while delivering drug at a rate slightly lower than predicted. There were no cases of pump over-infusion. There is a statistically significant decrease in flow rate accuracy over the lifespan of the pump.
Conclusions:
SynchroMed II pumps infuse at slightly less than their predicted rate while remaining within the manufacturer's specifications. No pump over-infusions were noted. Pump flow rate declines over time. Further study is warranted to assess the impact of this flow rate decrease on patient treatment and safety.
Related Concept Videos
03:37Uncertainty in Measurement: Accuracy and Precision
01:52Accuracy and Precision
02:07Improving Translational Accuracy
02:07Improving Translational Accuracy
01:30ATP Driven Pumps III: V-type Pumps
The peripheral or cytosolic V1 domain with eight subunits is involved in ATP hydrolysis. The integral or transmembrane V0 domain containing at least five subunits...
01:34ATP Driven Pumps II: P-type Pumps
A typical P-type pump has three cytosolic domains: nucleotide-binding (N), phosphorylation (P), and activator (A) domains. These domains are connected to the membrane-spanning helices by short amino acid segments. ATP hydrolysis and covalent phosphoenzyme intermediate formation are crucial parts of the catalytic cycle. At the highly...