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Updated: Jan 27, 2026

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Comment on article: “Zika, afebrile disease?”

Beuy Joob1, Viroj Wiwanitkit

  • 1Sanitation 1 Medical Academic Center. Bangkok, Thailand

Revista Medica Del Instituto Mexicano Del Seguro Social
|March 20, 2019
PubMed
Summary

Zika virus infection often presents without fever, particularly in endemic areas like Indochina. Asymptomatic cases are common, making diagnosis challenging without laboratory confirmation.

Area of Science:

  • Virology
  • Epidemiology
  • Infectious Diseases

Background:

  • Zika virus infection is endemic in Indochina, with a significant proportion of cases being asymptomatic.
  • Afebrile (without fever) presentations of Zika virus disease are frequently observed in this region.
  • While non-purulent conjunctivitis and rash can occur, they are less common than asymptomatic or afebrile presentations.

Discussion:

  • The high incidence of asymptomatic Zika virus infections poses diagnostic challenges.
  • Relying solely on symptoms like conjunctivitis or rash for diagnosing Zika virus may be unreliable due to their lower frequency compared to asymptomatic cases.
  • The absence of fever does not rule out Zika virus infection, especially in endemic populations.

Key Insights:

  • Asymptomatic Zika virus infection is prevalent in Indochina.
Keywords:
Flavivirus InfectionsZika Virus InfectionDiagnosisFever

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  • Afebrile illness is a common manifestation of Zika virus in endemic settings.
  • Laboratory testing is crucial for diagnosing Zika virus, particularly in asymptomatic or afebrile cases.

    • Outlook:

    • Further research is needed to improve diagnostic strategies for asymptomatic and afebrile Zika virus infections.
    • Enhanced surveillance and accessible laboratory testing are essential for managing Zika virus in endemic regions.
    • Understanding the spectrum of Zika virus presentation is critical for public health interventions.