Related Experiment Video

Updated: Jan 27, 2026

Inducing Apical Periodontitis in Mice
10:26

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

13.0K

Serum microRNAs and chronic periodontitis: A case-control study

Toshiki Yoneda1, Takaaki Tomofuji2, Daisuke Ekuni1

  • 1Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.

Archives of Oral Biology
|March 20, 2019
PubMed
Abstract

Insights

Researchers identified specific microRNAs (miRNAs) in the blood that may serve as biomarkers for chronic periodontitis. This study investigated serum miRNA levels in patients with and without periodontitis.

Area of Science:

  • Oral biology
  • Molecular diagnostics
  • Biomarker discovery

Background:

  • Periodontitis is linked to altered microRNA (miRNA) expression in periodontal tissues.
  • The relationship between periodontitis and serum miRNA levels remains unexplored.

Purpose of the Study:

  • To investigate serum microRNA (miRNA) levels in patients with chronic periodontitis.
  • To identify potential serum biomarkers for periodontitis.

Main Methods:

  • A case-control study involving 30 healthy individuals and 30 patients with chronic periodontitis.
  • Serum samples analyzed using microarray and real-time PCR for miRNA profiling.

Main Results:

  • Microarray analysis revealed seven differentially expressed miRNAs between groups (p < 0.05).
  • Real-time PCR confirmed elevated levels of hsa-miR-664a-3p, hsa-miR-501-5p, and hsa-miR-21-3p in periodontitis patients (p < 0.05).

Conclusions:

  • Hsa-miR-664a-3p, hsa-miR-501-5p, and hsa-miR-21-3p are potential serum biomarkers for chronic periodontitis.
  • These miRNAs could aid in non-invasive diagnosis and monitoring of periodontitis.
Keywords:
BiomarkersCase-control studyPeriodontitismicroRNAsserum

More Related Videos

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model06:14

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Published on: February 17, 2023

5.1K
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

12.3K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.2K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.0K
Serum Laboratory Studies, Stool Test, Breath Test01:30

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
816
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
424
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
427
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
605