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Related Experiment Video

Updated: Jan 27, 2026

Inducing Apical Periodontitis in Mice

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

Serum microRNAs and chronic periodontitis: A case-control study.

Toshiki Yoneda¹, Takaaki Tomofuji², Daisuke Ekuni¹

¹Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.

Archives of Oral Biology

|March 20, 2019

Summary

Researchers identified specific microRNAs (miRNAs) in the blood that may serve as biomarkers for chronic periodontitis. This study investigated serum miRNA levels in patients with and without periodontitis.

Keywords:

Biomarkers Case-control study Periodontitis microRNAs serum

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Area of Science:

Oral biology
Molecular diagnostics
Biomarker discovery

Background:

Periodontitis is linked to altered microRNA (miRNA) expression in periodontal tissues.
The relationship between periodontitis and serum miRNA levels remains unexplored.

Purpose of the Study:

To investigate serum microRNA (miRNA) levels in patients with chronic periodontitis.
To identify potential serum biomarkers for periodontitis.

Main Methods:

A case-control study involving 30 healthy individuals and 30 patients with chronic periodontitis.
Serum samples analyzed using microarray and real-time PCR for miRNA profiling.

Main Results:

Microarray analysis revealed seven differentially expressed miRNAs between groups (p < 0.05).
Real-time PCR confirmed elevated levels of hsa-miR-664a-3p, hsa-miR-501-5p, and hsa-miR-21-3p in periodontitis patients (p < 0.05).

Conclusions:

Hsa-miR-664a-3p, hsa-miR-501-5p, and hsa-miR-21-3p are potential serum biomarkers for chronic periodontitis.
These miRNAs could aid in non-invasive diagnosis and monitoring of periodontitis.