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Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
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Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

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High-Level Mupirocin Resistance in Staphylococcus spp. among Health Care Workers in a Tertiary Care Hospital

E Kavitha1,2, R Srikumar3

  • 1Research Scholar, Bharath University, Chennai, India, kavimicro23@gmail.com.

Pharmacology
|March 20, 2019
PubMed
Abstract

Insights

High-level mupirocin resistance is prevalent in coagulase-negative staphylococci (CONS) nasal carriage, not Staphylococcus aureus. This finding is crucial for judicious antibiotic use in healthcare settings.

Area of Science:

  • Clinical Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Nasal carriage of Staphylococcus aureus is common in healthcare workers.
  • Mupirocin is a primary antibiotic for treatment, but resistance is increasing.
  • Resistance can be low-level or high-level in isolated strains.

Purpose of the Study:

  • To screen for high-level mupirocin resistance in Staphylococcus strains.
  • Utilize the Kirby Bauer disk diffusion method for screening.

Main Methods:

  • Tested 200 clinical isolates for high-level mupirocin resistance.
  • Employed the disk diffusion method with Himedia disks.

Main Results:

  • 26% S. aureus and 87% coagulase-negative staphylococci (CONS) were isolated.
  • Mupirocin resistance was found only in CONS (15% low-level, 8% high-level).
  • No mupirocin resistance was observed in Staphylococcus aureus.

Conclusions:

  • Mupirocin resistance identified primarily in CONS.
  • Judicious antibiotic utilization is guided by resistance data.
  • Effective treatment of nasal carriage can be improved.
Keywords:
Antibiotic resistanceKirby Bauer disk diffusion methodLow-level and high-level mupirocin resistance

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