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Related Experiment Video

Updated: Jan 27, 2026

Selective Capture of 5-hydroxymethylcytosine from Genomic DNA

Selective Capture of 5-hydroxymethylcytosine from Genomic DNA

Published on: October 5, 2012

Selective virus capture via hexon imprinting.

Manuela Gast¹, Harald Sobek², Boris Mizaikoff¹

¹Institute of Analytical and Bioanalytical Chemistry, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany.

Materials Science & Engineering. C, Materials for Biological Applications

|March 21, 2019

Summary

This summary is machine-generated.

Researchers developed synthetic polymer beads that selectively bind to human Adenovirus type 5 (hAdV5). This imprinting technique uses the viral hexon protein for precise virus capture, showing high selectivity in binding studies.

Keywords:

Epitope imprinting Hexon protein Human Adenovirus type 5 (hAdV5)Molecular imprinting Protein imprinting Quantitative polymerase chain reaction (qPCR)Virus

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Last Updated: Jan 27, 2026

Selective Capture of 5-hydroxymethylcytosine from Genomic DNA

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Published on: October 5, 2012

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In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses

In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses

Published on: September 7, 2022

Area of Science:

Biomaterials Science
Virology
Nanotechnology

Background:

Developing selective molecular recognition materials is crucial for diagnostics and therapeutics.
Viral proteins, like the hexon protein of human Adenovirus type 5 (hAdV5), offer specific structural templates.
Existing methods for virus capture may lack specificity or efficiency.

Purpose of the Study:

To create synthetic polymer beads with high selectivity for a specific virus.
To utilize the hexon protein of hAdV5 as a molecular template for imprinting.
To validate the binding specificity and morphology of the imprinted beads.

Main Methods:

Molecular imprinting technique using the viral hexon protein of hAdV5 as a template.
Synthesis of functional polymer beads designed for supramolecular target binding.
Binding assays involving hAdV5 and Minute Virus of Mice (MVM) for competitive rebinding studies.
Scanning electron microscopy (SEM) for morphological characterization of the imprinted beads.

Main Results:

Successfully generated synthetic polymer beads with specific binding capabilities.
Demonstrated exquisite selectivity of the imprinted beads for hAdV5 over MVM in binding studies.
Confirmed the functional imprinting of the hexon protein onto the polymer bead surface.
SEM analysis confirmed the morphology of the imprinted beads.

Conclusions:

The developed imprinting technique effectively creates polymer beads for selective supramolecular target binding.
The hexon protein of hAdV5 serves as an effective template for generating virus-specific imprinted polymers.
These selective polymer beads show significant potential for applications in virus detection and purification.