Related Experiment Video
Updated: Jan 27, 2026
06:45
In Vitro and In Vivo Delivery of Magnetic Nanoparticle Hyperthermia Using a Custom-Built Delivery System
Published on: July 2, 2020
4.8K
Polypseudorotaxane functionalized magnetic nanoparticles as a dual responsive carrier for roxithromycin delivery
Yu Ke1, Xiaoye Zhang1, Caikun Liu1
1Department of Biomedical Engineering, Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
Summary
A novel magnetic and pH-responsive nanocomposite (CDMNP-PEG-CD) was developed for targeted antibacterial therapy. This system enhances drug delivery and reduces side effects by responding to environmental triggers.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Developing targeted drug delivery systems is crucial for enhancing therapeutic efficacy and minimizing side effects.
- Magnetic and pH-responsive materials offer unique advantages for controlled drug release.
- Iron oxide nanoparticles functionalized with cyclodextrin and polyethylene glycol can improve drug loading and targeting.
Purpose of the Study:
- To prepare and characterize a magnetic-pH dual responsive drug delivery system for antibacterial therapy.
- To evaluate the drug loading capacity, stability, and responsiveness of the developed nanocomposite.
- To assess the in vitro antibacterial activity and drug release profile of the roxithromycin-loaded system.
Main Methods:
- Synthesis of iron oxide (Fe3O4) core functionalized with beta-cyclodextrin (β-CD) and a polypseudorotaxanes shell (CDMNP-PEG-CD).
- Characterization of nanocomposite properties including size, superparamagnetism, stability, and serum albumin interaction.
- In vitro drug release studies at different pH values (1.0, 7.4, 8.0) and antibacterial activity assays against E. coli and S. aureus.
Main Results:
- The CDMNP-PEG-CD nanocomposites exhibited a hydrodynamic diameter of ~168 nm, were cytocompatible, superparamagnetic, and stable.
- Drug release was significantly pH-responsive, with ~76% released at pH 1.0 within 30 min, 1.6-fold higher than at pH 7.4 and 2-fold higher than at pH 8.0.
- The nanocomposites demonstrated positive antibacterial activity against E. coli and S. aureus, with enhanced efficacy against E. coli.
Conclusions:
- The developed magnetic-pH dual responsive nanocomposite (CDMNP-PEG-CD) is a promising platform for targeted antibacterial therapy.
- The system allows for efficient loading and controlled release of hydrophobic drugs, potentially reducing side effects.
- Further applications in localized and concentrated drug delivery for various therapeutic needs are anticipated.
Related Concept Videos
01:24Electron Carriers
91.7K
Electron carriers can be thought of as electron shuttles. These compounds can easily accept electrons (i.e., be reduced) or lose them (i.e., be oxidized). They play an essential role in energy production because cellular respiration is contingent on the flow of electrons.
Over the many stages of cellular respiration, glucose breaks down into carbon dioxide and water. Electron carriers pick up electrons lost by glucose in these reactions, temporarily storing and releasing them into the electron...
Over the many stages of cellular respiration, glucose breaks down into carbon dioxide and water. Electron carriers pick up electrons lost by glucose in these reactions, temporarily storing and releasing them into the electron...
91.7K
01:21Carrier Transport
937
The generation of electrical current in semiconductors is fundamentally driven by two mechanisms: drift and diffusion. These processes are essential for the functionality and performance of semiconductor-based devices.
Drift Current:
The drift of charge carriers is started by an external electric field (E). Charged particles, such as electrons and holes, experience an acceleration between collisions with lattice atoms. For electrons, this results in a drift velocity (vd) given by:
Drift Current:
The drift of charge carriers is started by an external electric field (E). Charged particles, such as electrons and holes, experience an acceleration between collisions with lattice atoms. For electrons, this results in a drift velocity (vd) given by:
937
01:06Carrier-Mediated Transport
1.3K
Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
1.3K
01:22Carrier Generation and Recombination
1.3K
Carrier generation is the process by which electron-hole pairs (EHPs) are created within the semiconductor. In direct-bandgap semiconductors, such as gallium arsenide (GaAs), this occurs efficiently when energy absorption prompts valence electrons to leap into the conduction band, leaving behind holes.
This process is given by the generation rate G and is efficient due to the conservation of momentum between the valence band maximum and conduction band minimum.
Indirect generation involves an...
This process is given by the generation rate G and is efficient due to the conservation of momentum between the valence band maximum and conduction band minimum.
Indirect generation involves an...
1.3K
01:42The ADP/ATP Carrier Protein
4.2K
ADP/ATP carrier or AAC protein is the most abundant carrier protein in the inner mitochondrial membrane. It transports large quantities of ADP and ATP, equivalent to the average human body weight, every day. Among other transporters, ACC protein is one of the best-studied members of the mitochondrial carrier protein family. The ADP/ATP carrier protein comprises two transmembrane helices connected to a loop and a single alpha-helix on the matrix side. It switches between two conformational...
4.2K
03:02Colors and Magnetism
14.0K
Color in Coordination Complexes
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human...
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human...
14.0K