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Synthesis and Catalytic Performance of Gold Intercalated in the Walls of Mesoporous Silica
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Functionalized mesoporous silica nanoparticles and biomedical applications.

Thai Thanh Hoang Thi1, Van Du Cao2, Thi Nhu Quynh Nguyen2

  • 1Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam.

Materials Science & Engineering. C, Materials for Biological Applications
|March 21, 2019
PubMed
Summary

Mesoporous silica nanoparticles (MSNs) offer unique properties for biomedical applications. Functionalized MSNs respond to stimuli, revolutionizing drug delivery, imaging, and therapeutics.

Keywords:
CatalystControlled releaseDiagnostic imagingDrug deliveryMSNNanocarriersNanoparticlesStimuli-responsive delivery systemTheranostic applications

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Mesoporous silica nanoparticles (MSNs) have garnered significant scientific interest since the 1990s.
  • Their unique physiochemical properties include high porosity, large surface area, tunable sizes, and biocompatibility.
  • These characteristics enable efficient encapsulation, controlled release, and intracellular delivery of bioactive molecules.

Purpose of the Study:

  • This review focuses on the recent fabrication of functionalized MSNs.
  • It discusses their potential applications in drug delivery, therapeutic treatments, and diagnostic imaging.
  • The review also explores their use as biocatalysts and potential clinical applications.

Main Methods:

  • The review synthesizes information on the fabrication of functionalized MSNs.
  • It highlights MSNs responsive to various stimuli like temperature, pH, light, and biochemicals.
  • The discussion covers applications based on these responsive properties.

Main Results:

  • Functionalized MSNs demonstrate remarkable versatility in biomedical engineering.
  • Stimuli-responsive MSNs offer advanced capabilities for targeted drug delivery and diagnostics.
  • These nanoparticles are effective in therapeutic treatments and as biocatalysts.

Conclusions:

  • Functionalized MSNs represent a significant advancement in biomedical applications.
  • Their stimuli-responsive nature unlocks novel therapeutic and diagnostic potentials.
  • Further research into clinical applications and overcoming challenges is warranted.