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Behavioral effects evoked by the beta globin-derived nonapeptide LVV-H6
Kellen Rosa da Cruz1, Danielle Ianzer1, Larissa Córdova Turones1
1Department of Physiological Sciences, Institute of Biological Sciences, Federal University of Goiás, Goiânia, GO, Brazil.
Peptides
|March 21, 2019
Summary
LVV-hemorphin-6 (LVV-h6) peptide shows anxiolytic effects through non-opioid pathways and antidepressant effects via opioid pathways. This hemoglobin-derived peptide influences behavior without altering stress responses.
Area of Science:
- Neuroscience
- Pharmacology
- Behavioral Science
Background:
- LVV-hemorphin-6 (LVV-h6) is a bioactive peptide derived from hemoglobin.
- Its effects may involve opioid or AT4/IRAP receptors, suggesting potential behavioral modulation.
Purpose of the Study:
- To investigate the behavioral effects of LVV-h6 in rats.
- To determine if LVV-h6 influences anxiety-like behavior, depression-like behavior, and reactivity to stress.
- To elucidate the receptor pathways involved in LVV-h6's actions.
Main Methods:
- Male Wistar rats were administered LVV-h6 (153 nmol/kg i.p.) or vehicle.
- Behavioral tests included the open field (OF), elevated plus maze (EPM), and forced swimming test (FST).
- Cardiovascular and neuroendocrine responses to air jet stress were assessed. Receptor antagonists (atosiban, naltrexone) and an enzyme inhibitor (AMPT) were used to explore mechanisms.
Main Results:
- LVV-h6 demonstrated anxiolytic-like and antidepressant-like effects.
- Locomotion, neuroendocrine, and cardiovascular responses to stress remained unchanged.
- The anxiolytic effect was not blocked by oxytocin receptor antagonists or catecholaminergic inhibitors, but the antidepressant effect was reversed by opioid receptor antagonists.
Conclusions:
- LVV-h6 modulates anxiety-like behavior via non-oxytocinergic, non-catecholaminergic, and non-opioid pathways.
- The antidepressant-like effects of LVV-h6 are mediated through opioid pathways.
- LVV-h6 presents distinct mechanisms for anxiolytic and antidepressant actions.
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