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Updated: Jan 27, 2026

Investigating the Phagocytosis of Leishmania using Confocal Microscopy
Published on: July 29, 2021
White jute (Corchorus capsularis L.) leaf extract has potent leishmanicidal activity against Leishmania donovani
Pijush Kanti Pramanik1, Dibyendu Paik1, Asmita Pramanik1
1Department of Biochemistry and Biophysics, University of Kalyani, Kalyani 741235, West Bengal, India.
Abstract:
In pursuit of effective, safe and affordable antileishmanial drugs, the current study was designed to explore Corchorus capsularis L. leaf extract (CCEx) as an effective leishmanicidal substitute against Leishmania donovani. The leaf extract displays potent antileishmanial activity against L. donovani promastigotes with an IC50 value of 79.00 ± 0.3 μg/ml. CCEx also significantly induces intracellular reactive oxygen species (ROS) with a concomitant decrease in the level of non-protein thiols in virulent parasites. Additionally, CCEx treatment induces substantial morphological alterations in parasites. Moreover, reagent-based phytochemical analysis of the extract revealed the presence of various phytochemical constituents. Further study is underway to identify the bioactive component(s) or fraction(s) of CCEx through bioassay-guided fractionation.
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