Related Experiment Video
Updated: Jan 27, 2026
03:55
Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
965
Threatening cancer with nanoparticle aided combination oncotherapy
1Department of Pharmaceutics, Institute of Pharmacy, Nirma University, SG Highway, Chharodi, Ahmedabad 382481, Gujarat, India.
Summary
Combination cancer therapy is essential for advanced disease. Nanotechnology offers solutions for delivering multiple drugs, overcoming challenges in combination oncotherapy for improved patient outcomes.
Area of Science:
- Oncology
- Nanotechnology
- Drug Delivery
Background:
- Combination therapy is crucial for treating cancers with high tumor burden, chemoresistance, and advanced stages.
- Challenges in combination therapy include differing physicochemical properties and pharmacokinetics of multiple anticancer agents.
- Nanotechnology provides innovative solutions to optimize the delivery of combination oncotherapies.
Purpose of the Study:
- To review nanocarrier-based delivery systems for combination oncotherapy.
- To highlight the benefits of combination therapy over monotherapy.
- To discuss challenges in translating nanotechnology-based combination oncotherapy to clinical practice.
Main Methods:
- Review of nanocarrier systems for delivering diverse payloads (chemotherapeutics, siRNA, radiosensitizers, etc.).
- Exploration of various nano-delivery systems including liposomes, polymeric nanoparticles, micelles, and inorganic nanoparticles.
- Discussion of nanoformulation strategies for successful combination oncotherapy.
Main Results:
- Nanoparticles offer unique colloidal properties and targeting strategies for optimized combination drug delivery.
- Numerous nano-delivery systems have been explored for formulating multidrug delivery systems.
- Nanotechnology facilitates overcoming limitations of traditional combination chemotherapy.
Conclusions:
- Nanotechnology-based combination oncotherapy presents significant advantages over single-agent treatments.
- Various nanoformulation strategies exist to enable effective combination cancer therapy.
- Obstacles remain in the clinical translation of these advanced nanotherapies.
Keywords:
AngiogenesisColloidal carriersNanoparticulate systemProdrugsReceptorsTargeted drug deliveryMore Related Videos
08:57Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
Published on: October 5, 2017
11.4K
08:03Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
Published on: December 1, 2016
9.5K
Related Concept Videos
01:21Impedance Combination
749
Consider a string of christmas lights, each bulb symbolizing an impedance element. In this series configuration, the flow of electric current remains uniform across every component. This behavior aligns with Kirchhoff's Voltage Law (KVL), which asserts that the total impedance in such a setup equals the sum of individual impedances—akin to resistors in series. It follows that the voltage from the power source is distributed proportionally among these components, adhering to the voltage...
749
01:18Combination Of Resistors
3.7K
Electrical devices in any circuit can be connected either by series or parallel connections. Additionally, circuits can be connected involving both of these connections, known as combination or complex circuits. As these circuits have complex resistor connections, it is necessary to identify different parts as either series or parallel connections, then the whole combination of series and parallel resistors can be reduced to a single equivalent resistance. With the known equivalent resistance...
3.7K
02:18Cancer
54.2K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
54.2K
02:12What is Cancer?
14.4K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
14.4K
01:23Stresses under Combined Loadings
462
When analyzing a bent tube with a circular cross-section subjected to multiple forces, it is crucial to determine the stress distribution in order to maintain structural integrity under varied load conditions.
The process begins by slicing the tube at critical points and analyzing the internal forces and stress components at these sections, focusing on the centroid. Normal stresses, generated by axial forces and bending moments, are either compressive or tensile and vary across the section from...
The process begins by slicing the tube at critical points and analyzing the internal forces and stress components at these sections, focusing on the centroid. Normal stresses, generated by axial forces and bending moments, are either compressive or tensile and vary across the section from...
462
01:27Combined Effects of Drugs: Synergism
6.8K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
6.8K