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Dual roles of EZH2 in acute myeloid leukemia
Radek C Skoda1, Juerg Schwaller2
1Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland radek.skoda@unibas.ch.
Abstract:
In this issue of JEM, Basheer et al. (https://doi.org/10.1084/jem.20181276) describe opposing roles of the epigenetic regulator Ezh2 during initiation and maintenance of acute myeloid leukemia (AML). Ezh2 was found to have tumor suppressive and oncogenic functions in different phases of the same malignancy.
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