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Related Concept Videos

Personal Choice and Fate Attributions01:19

Personal Choice and Fate Attributions

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Some individuals interpret life events as a consequence of their personal choices and actions, while others believe that outcomes are dictated by fate or destiny. This divergence in perspective has been examined in psychological and cross-cultural studies, particularly in relation to religious faith and cultural beliefs about causality.Fate and Personal ResponsibilityPeople who emphasize personal responsibility view events as direct consequences of their decisions. For instance, breaking a leg...
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Whether solid, liquid, or gas, a substance's state depends on the order and arrangement of its particles (atoms, molecules, or ions). Particles in the solid pack closely together, generally in a pattern. The particles vibrate about their fixed positions but do not move or squeeze past their neighbors. In liquids, although the particles are closely spaced, they are randomly arranged. The position of the particles are not fixed—that is, they are free to move past their neighbors to...
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The physical form of a substance changes on changing its temperature. For example, raising the temperature of a liquid causes the liquid to vaporize (convert into vapor). The process is called vaporization—a surface phenomenon. Vaporization occurs when the thermal motion of the molecules overcome the intermolecular forces, and the molecules (at the surface) escape into the gaseous state. When a liquid vaporizes in a closed container, gas molecules cannot escape. As these gas phase molecules...
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Properties of Transition Metals02:58

Properties of Transition Metals

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Transition metals are defined as those elements that have partially filled d orbitals. As shown in Figure 1, the d-block elements in groups 3–12 are transition elements. The f-block elements, also called inner transition metals (the lanthanides and actinides), also meet this criterion because the d orbital is partially occupied before the f orbitals.
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Related Experiment Video

Updated: Jan 27, 2026

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
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Transition state dynamics during a stochastic fate choice.

Vlatka Antolović1, Tchern Lenn1, Agnes Miermont1

  • 1Laboratory for Molecular Cell Biology and Division of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.

Development (Cambridge, England)
|March 21, 2019
PubMed
Summary

Self-organising cells in Dictyostelium rapidly transition between distinct developmental fates. This cell fate bifurcation is linked to large-scale, shared transcriptome remodelling, not just fate-specific gene changes.

Keywords:
Attractor stateDictyosteliumMS2Single cell transcriptomicsStochastic gene expressionSymmetry-breaking

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Area of Science:

  • Developmental Biology
  • Cellular Self-Organisation
  • Molecular Biology

Background:

  • Cellular self-organisation generates diverse cell fates from uniform populations during development and regeneration.
  • Understanding the molecular mechanisms driving cell fate decisions in self-organising systems remains a challenge.
  • Dictyostelium discoideum provides a model system for studying developmental self-organisation, specifically cell segregation into stalk and spore fates.

Purpose of the Study:

  • To investigate the gene expression dynamics underlying cell fate bifurcation in Dictyostelium.
  • To characterise the developmental intermediates and transitions between progenitor, prespore, and prestalk cells.
  • To determine the relationship between fate-specific gene expression and global transcriptome changes during cell differentiation.

Main Methods:

  • Single-cell transcriptomics was employed on Dictyostelium multicellular aggregates.
  • Analysis focused on identifying distinct cell states and transcriptional transitions.
  • Gene expression patterns were compared between different cell types and developmental stages.

Main Results:

  • Cell fate transitions from progenitors to prespore and prestalk cells proceed through discrete intermediates.
  • Cell states were found to be discrete with rapid transitions, indicated by minimal overlap in fate markers.
  • Fate-specific transcriptomic changes constituted a small fraction of overall gene expression shifts.
  • Transcriptome divergence coincided with large-scale, shared remodelling of gene expression in both cell types.

Conclusions:

  • Cellular identity separation in Dictyostelium is tightly coupled to global transcriptome reorganisation common to differentiating fates.
  • The study reveals a novel model where broad transcriptional shifts precede or accompany discrete cell fate commitment.
  • These findings offer insights into the fundamental principles governing cell differentiation in self-organising biological systems.