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Updated: Aug 4, 2026

Measuring Rates of Herbicide Metabolism in Dicot Weeds with an Excised Leaf Assay
Published on: September 7, 2015
Atorvastatin (Lipitor) by MCR
Tryfon Zarganes-Tzitzikas1, Constantinos G Neochoritis1, Alexander Dömling1
1Department of Pharmacy, Drug Design group, University of Groningen, A. Deusinglaan 1, Groningen 9700 AV, The Netherlands.
Abstract:
A concise and convergent synthesis of the atorvastatin, the best-selling cardiovascular drug of all time, is presented. Our approach is based on an Ugi reaction, which shortens the current synthetic route and is advantageous over the published syntheses.
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