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Neurological Complications associated with Pediatric Liver Transplant in Namazi Hospital: One-Year Follow-Up

H Nemati1, K Kazemi1, A T Mokarram2

  • 1Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

International Journal of Organ Transplantation Medicine
|March 21, 2019
PubMed

Insights

Neurological complications after pediatric liver transplant (LT) were less frequent at Namazi Hospital. Convulsions were the most common neurological issue observed in this study.

Area of Science:

  • Pediatric Hepatology
  • Neuroscience
  • Transplant Surgery

Background:

  • Severe neurological events affect 13%-43% of liver transplant (LT) recipients, increasing morbidity and mortality.
  • Understanding post-LT neurological complications in pediatric patients is crucial for improving outcomes.

Purpose of the Study:

  • To determine the incidence of neurological complications in children undergoing liver transplantation at Namazi Hospital.
  • To identify potential predictors and outcomes associated with neurological complications post-pediatric LT.

Main Methods:

  • Retrospective review of medical records for 101 pediatric patients (1-18 years) who underwent LT between May 2016 and May 2017.
  • Analysis of demographic data, neurological complication occurrence, and preoperative variables.
  • Follow-up duration averaged 10.1 months.

Main Results:

  • The most frequent causes for LT were biliary atresia and progressive familial intrahepatic cholestasis.
  • 15.8% of patients experienced convulsions; 3.0% showed signs of peripheral neuropathy.
  • Overall survival was 73.3% after one year; no correlation found between age, sex, or underlying disease and neurological complications.

Conclusions:

  • Neurological complications were less common at this center compared to reported rates.
  • Convulsions represent the primary neurological manifestation following pediatric liver transplantation.
  • Age, sex, and the underlying liver disease did not correlate with the development of neurological complications.
Abstract

Keywords:
Liver transplantNeurological complicationPediatric

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