[Effect of antibiotics on the adhesive properties of microorganisms and an available model for its study]

The effect of benzylpenicillin, ampicillin, bicillin-3, carbenicillin, levomycetin, erythromycin, streptomycin and kanamycin on the adhesive properties of 9 test microbes including 5 strains of Lactobacillus from human microflora, 3 uropathornic strains of E. coli and 1 strain of S. aureus was studied with the method developed by the authors. The method is based on the use of formalinized human erythrocytes as macroorganism cells. It was shown that the antibiotic inhibitory effect on adhesion depended on mechanism of action of the antibiotics and their concentration, was associated with the level of the microbial adhesion and did not depend on the microbial sensitivity to the drugs.