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Updated: Jan 27, 2026

Intranuclear Microinjection of DNA into Dissociated Adult Mammalian Neurons
Published on: December 10, 2009
Non-convulsive status epilepticus associated with neuronal intranuclear inclusion disease: A case report and
Kazumasa Shindo1, Mai Tsuchiya1, Takanori Hata1
1Department of Neurology, University of Yamanashi, Yamanashi, Japan.
Abstract:
We report a case of neuronal intranuclear inclusion disease (NIID) confirmed by detection of intranuclear inclusions in a skin biopsy specimen. Brain magnetic resonance imaging showed mild cerebral atrophy and linear hyperintensities at the corticomedullary junction on diffusion-weighted images. This patient developed nonconvulsive status epilepticus with generalized periodic discharges on electroencephalography after recurrent symptoms of paroxysmal nausea and slowly progressive cognitive decline. There have been no previous reports of NIID with nonconvulsive status epilepticus to our knowledge. Since adult patients with NIID display a wide variety of clinical manifestations, skin biopsy should be considered in patients who have leukoencephalopathy of unknown origin.
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