Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

7.7K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
7.7K
Frequency-dependent Selection01:21

Frequency-dependent Selection

23.6K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
23.6K
Pleiotropy01:33

Pleiotropy

43.2K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
43.2K
The Tree of Life - Bacteria, Archaea, Eukaryotes02:40

The Tree of Life - Bacteria, Archaea, Eukaryotes

38.3K
The “tree of life” describes the evolution of life and the evolutionary relationships between organisms. The root of the tree is the common ancestor to all life on Earth. All other species radiate from this point, much like the branches of a tree. The numerous tips of these branches on the tree of life represent every living, or extant, species. Extinct species, which are species that no longer exist, can be found towards the center of the tree. Currently, these organisms, both...
38.3K
Genetic Lingo01:11

Genetic Lingo

114.3K
Overview
114.3K
Polygenic Traits01:18

Polygenic Traits

69.0K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
69.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The frequent exacerbator phenotype in bronchiectasis revisited: Data from EMBARC registry.

American journal of respiratory and critical care medicine·2026
Same author

ERS statement: Core outcome set for trials evaluating the management of community-acquired and nosocomial pneumonia in adults.

The European respiratory journal·2026
Same author

<i>In vitro</i> diagnostics for respiratory infections: current state and opportunities.

Breathe (Sheffield, England)·2026
Same author

Mucoactive therapies and the European Respiratory Society guideline for adult bronchiectasis: what now after the CLEAR trial?

The European respiratory journal·2026
Same author

Comorbid diabetes disease severity and microbial changes in patients with bronchiectasis: a combined analysis of data from the EMBARC, EMBARC-India, Australian, and BE-China registries.

The Lancet. Respiratory medicine·2026
Same author

Bronchiectasis in Italy: an analysis of the EMBARC registry.

ERJ open research·2026

Related Experiment Video

Updated: Jan 27, 2026

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

1.9K

Bronchiectasis phenotypes.

Patricia Chang-Macchiu1, Letizia Traversi2, Eva Polverino1,3

  • 1Pneumology Department, Hospital Universitari Vall d' Hebron (HUVH), Institut de Recerca Vall d'Hebron (VHIR), Barcelona, Spain.

Current Opinion in Pulmonary Medicine
|March 21, 2019
PubMed
Summary
This summary is machine-generated.

Identifying clinical phenotypes in bronchiectasis is crucial for personalized management. Further research into host-related factors (endotypes) is needed to understand disease severity and improve patient outcomes.

More Related Videos

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
07:41

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension

Published on: March 17, 2022

3.4K
Quantification of Orofacial Phenotypes in Xenopus
09:26

Quantification of Orofacial Phenotypes in Xenopus

Published on: November 6, 2014

10.3K

Related Experiment Videos

Last Updated: Jan 27, 2026

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

1.9K
Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
07:41

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension

Published on: March 17, 2022

3.4K
Quantification of Orofacial Phenotypes in Xenopus
09:26

Quantification of Orofacial Phenotypes in Xenopus

Published on: November 6, 2014

10.3K

Area of Science:

  • Pulmonology
  • Respiratory Medicine
  • Clinical Phenotyping

Background:

  • Bronchiectasis is a chronic respiratory disease with varied clinical presentations and outcomes.
  • Heterogeneity in bronchiectasis necessitates personalized management strategies.
  • Current phenotyping approaches lack comprehensive understanding of disease determinants.

Purpose of the Study:

  • To review current literature on clinical phenotypes of bronchiectasis.
  • To identify priorities for future research in bronchiectasis phenotyping.
  • To explore the role of host-related factors in disease severity.

Main Methods:

  • Literature review of studies stratifying bronchiectasis patients.
  • Analysis of classification by cause, microbiology, and associated conditions.
  • Examination of cluster analyses and host-related factors.

Main Results:

  • Classification by cause is clinically meaningful only for specific conditions like allergic bronchopulmonary aspergillosis or immunodeficiencies.
  • Microbiological stratification shows clinical utility, but host factors remain unpredictable.
  • Existing phenotyping attempts highlight the need for deeper investigation into endotypes.

Conclusions:

  • Despite efforts, identifying definitive bronchiectasis phenotypes remains challenging.
  • Host-related factors (endotypes) significantly influence disease severity and clinical outcomes.
  • Future research should prioritize elucidating the role of endotypes for improved bronchiectasis management.