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Meal for Two: Human Cytomegalovirus-Induced Activation of Cellular Metabolism
Irene Rodríguez-Sánchez1, Joshua Munger2,3
1Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA. Irene_RodriguezSanchez@URMC.Rochester.edu.
Abstract:
Viruses are parasites that depend on the host cell's metabolic resources to provide the energy and molecular building blocks necessary for the production of viral progeny. It has become increasingly clear that viruses extensively modulate the cellular metabolic network to support productive infection. Here, we review the numerous ways through which human cytomegalovirus (HCMV) modulates cellular metabolism, highlighting known mechanisms of HCMV-mediated metabolic manipulation and identifying key outstanding questions that remain to be addressed.
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