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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Related Experiment Video

Updated: Jan 27, 2026

Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood
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Long Non-Coding RNA in Vascular Disease and Aging.

Diewertje I Bink1, Noelia Lozano-Vidal2, Reinier A Boon3,4,5

  • 1Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VU University, 1081HV Amsterdam, The Netherlands. d.bink1@vumc.nl.

Non-Coding RNA
|March 22, 2019
PubMed
Summary

Long non-coding RNAs (lncRNAs) offer new therapeutic targets for cardiovascular diseases, which are a leading cause of death, particularly in the elderly. This review explores lncRNAs involved in vascular disease and aging for potential diagnostic and therapeutic strategies.

Keywords:
aginglncRNAvascular disease

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Area of Science:

  • Biomedical research
  • Molecular biology
  • Genetics

Background:

  • Cardiovascular diseases (CVDs) are the primary cause of mortality in Western nations, disproportionately affecting the elderly population.
  • Increasing life expectancy is projected to exacerbate the prevalence of CVDs, intensifying the healthcare burden.
  • Novel therapeutic strategies are urgently needed to address the growing number of patients with cardiovascular conditions.

Purpose of the Study:

  • To review the role of long non-coding RNAs (lncRNAs) in vascular disease and aging.
  • To identify potential diagnostic, preventive, and therapeutic targets within lncRNA pathways.
  • To provide insights into novel molecular mechanisms underlying cardiovascular conditions.

Main Methods:

  • Literature review of studies on lncRNAs in vascular disease and aging.
  • Analysis of lncRNA regulation in the context of cardiovascular health and disease.
  • Identification of lncRNAs implicated in age-related vascular changes.

Main Results:

  • Long non-coding RNAs are emerging as key regulators in vascular disease and aging processes.
  • Specific lncRNAs show altered expression patterns associated with vascular pathologies and senescence.
  • These lncRNAs represent a novel class of molecules with therapeutic potential.

Conclusions:

  • Long non-coding RNAs are promising candidates for developing new diagnostic and therapeutic interventions for cardiovascular diseases.
  • Targeting lncRNAs may offer novel pathways to combat vascular disease and mitigate aging-related cardiovascular decline.
  • Further research into lncRNA function is crucial for advancing cardiovascular medicine.