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Updated: Jan 27, 2026

Activating Autophagy by Aerobic Exercise in Mice
Published on: February 3, 2017
The BARA necessities of PtdIns 3-kinase activation in autophagy
Chunmei Chang1,2, Lindsey N Young1,2,3, James H Hurley1,2,3
1a Department of Molecular and Cell Biology , University of California , Berkeley , CA , USA.
Abstract:
Macroautophagy/autophagy is an evolutionarily conserved degradation system with fundamental biological functions. The activation of the class III phosphatidylinositol 3-kinase (PtdIns3K) complexes and the subsequent production of phosphatidylinositol 3-phosphate (PtdIns3P) are pivotal to autophagy. Using a combination of structural biology, biochemistry, and biophysics, we revealed how the non-catalytic subunit BECN1 serves as a membrane-binding switch in the regulation of PtdIns3K complexes and autophagy.
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