Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

497
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
497
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

476
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
476
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

2.3K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.3K
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

846
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
846
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

763
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
763
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

528
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
528

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biological therapies for inflammatory pouch disorders: insights and outcomes from the RESERVO study of GETECCU.

Therapeutic advances in gastroenterology·2026
Same author

Vedolizumab to prevent postoperative recurrence of Crohn's disease (REPREVIO): a multicentre, double-blind, randomised, placebo-controlled trial.

The lancet. Gastroenterology & hepatology·2024
Same author

Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCU.

Therapeutic advances in gastroenterology·2024
Same author

High incidence of surgery and initiation of medical therapies after colectomy for ulcerative colitis or inflammatory bowel disease unclassified.

Gastroenterologia y hepatologia·2022
Same author

Effectiveness and Safety of Ustekinumab in Elderly Patients with Crohn's Disease: Real World Evidence From the ENEIDA Registry.

Journal of Crohn's & colitis·2022
Same author

Performance of Screening Strategies for Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease: Results from the ENEIDA Registry of GETECCU.

Journal of clinical medicine·2022

Related Experiment Video

Updated: Jan 27, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
11:07

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding

Published on: September 21, 2011

16.9K

Steroids and Postoperative Complications in IBD.

Antonio López-Sanromán1

  • 1Gastroenterology and Hepatology Department, Hospital Ramón y Cajal, 28034 Madrid, Spain.

Current Drug Targets
|March 22, 2019
PubMed
Summary

Corticosteroids, while beneficial for Inflammatory Bowel Disease, increase surgical risks. Careful perioperative management, considering nutrition, is crucial to mitigate these steroid-related complications.

Keywords:
Corticosteroidscomplicationscrohn’s diseaseinflammatory bowel disease.surgeryulcerative colitis

More Related Videos

A Postoperative Evaluation Guideline for Computer-Assisted Reconstruction of the Mandible
10:42

A Postoperative Evaluation Guideline for Computer-Assisted Reconstruction of the Mandible

Published on: January 28, 2020

6.9K
Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications
09:41

Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications

Published on: May 10, 2024

1.7K

Related Experiment Videos

Last Updated: Jan 27, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
11:07

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding

Published on: September 21, 2011

16.9K
A Postoperative Evaluation Guideline for Computer-Assisted Reconstruction of the Mandible
10:42

A Postoperative Evaluation Guideline for Computer-Assisted Reconstruction of the Mandible

Published on: January 28, 2020

6.9K
Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications
09:41

Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications

Published on: May 10, 2024

1.7K

Area of Science:

  • Gastroenterology and Surgery

Background:

  • Corticosteroids are a cornerstone in managing Inflammatory Bowel Disease (IBD).
  • These potent anti-inflammatory agents carry significant potential adverse effects.
  • Perioperative use of corticosteroids requires careful consideration due to associated risks.

Purpose of the Study:

  • To highlight the increased risk of surgical complications in patients on corticosteroids.
  • To emphasize the need for caution when managing IBD patients undergoing surgery while on steroids.
  • To advocate for a multidisciplinary approach in perioperative care.

Main Methods:

  • Review of existing literature on corticosteroid use in IBD and surgical outcomes.
  • Analysis of potential infectious and non-infectious complications.
  • Consideration of adjunctive factors like nutritional status.

Main Results:

  • Perioperative corticosteroid use is associated with a higher likelihood of surgical complications.
  • Both infectious and non-infectious complications are more prevalent in steroid-treated surgical patients.
  • Nutritional status is a key factor to consider alongside steroid management.

Conclusions:

  • Avoidance of corticosteroids in the perioperative period is recommended when feasible.
  • A comprehensive, multidisciplinary approach is essential for managing IBD patients around surgery.
  • Mitigating steroid-induced risks requires attention to patient factors including nutrition.