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Pyramidal system involvement in progressive supranuclear palsy - a clinicopathological correlation.

Zuzana Stejskalova1,2,3, Zdenek Rohan4,5, Robert Rusina6,7

  • 1Department of Pathology and Molecular Medicine Third Faculty of Medicine, Charles University and Thomayer Hospital, Videnska 800, 14059, Prague 4 - Krc, Czech Republic.

BMC Neurology
|March 22, 2019
PubMed
Summary

This study analyzed pyramidal motor system pathology in progressive supranuclear palsy (PSP). Tau pathology is common in PSP, particularly in Richardson's syndrome, but doesn't correlate with motor symptoms.

Keywords:
Atypical parkinsonismProgressive supranuclear palsySpinal cordTauopathies

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Area of Science:

  • Neuropathology
  • Neurodegenerative Diseases
  • Motor Neuron Diseases

Background:

  • Progressive supranuclear palsy (PSP) is a neurodegenerative disease with complex motor symptoms.
  • Understanding pyramidal motor system involvement is crucial for PSP diagnosis and management.

Purpose of the Study:

  • To conduct a detailed neuropathological analysis of the pyramidal motor system in progressive supranuclear palsy (PSP).
  • To establish clinical-pathological correlations of pyramidal motor system pathology in PSP cases.

Main Methods:

  • Analyzed pyramidal motor system pathology in 18 neuropathologically confirmed PSP cases.
  • Utilized immunohistochemistry (anti-tau AT8 clone) to evaluate tau pathology.
  • Retrospectively assessed clinical manifestations of motor neuron involvement and subtyped PSP cases.

Main Results:

  • Pyramidal motor system involvement was observed across various PSP subtypes.
  • A significantly higher tau pathology load was found in the pyramidal system of PSP-Richardson's syndrome compared to other subtypes.
  • No significant correlation was found between pyramidal system tau pathology and related motor symptoms.

Conclusions:

  • Tau pathology in the spinal cord and pyramidal motor system is prevalent in progressive supranuclear palsy (PSP).
  • Neuropathological findings may aid in distinguishing classic Richardson's syndrome from other PSP subtypes.