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Citrullination in Cancer

Arseniy E Yuzhalin1

  • 1CRUK/MRC Oxford Institute for Radiation Oncology, Oxford, United Kingdom. arseniy.yuzhalin@oncology.ox.ac.uk.

Cancer Research
|March 22, 2019
PubMed

Insights

Arginine deimination, or citrullination, significantly impacts cancer progression by influencing apoptosis, metastasis, and immune responses. Further research is crucial to explore its role in tumor biology and potential therapeutic applications.

Area of Science:

  • Biochemistry
  • Oncology
  • Immunology

Background:

  • Posttranslational modifications, including arginine deimination (citrullination), are linked to various diseases.
  • Citrullination plays a key role in rheumatoid arthritis pathogenesis.
  • Emerging evidence highlights citrullination's involvement in cancer progression.

Purpose of the Study:

  • To provide a comprehensive review of citrullination's influence on tumor biology.
  • To critically analyze findings related to citrullination in cancer.
  • To explore potential diagnostic and therapeutic applications of citrullination in oncology.

Main Methods:

  • Literature review and critical analysis of existing research.
  • Synthesis of findings on citrullination's role in apoptosis, differentiation, EMT, and metastasis.
  • Discussion of citrullinated antigens in cancer immunotherapy.
  • Examination of citrullination as a cancer biomarker.
  • Review of neutrophil extracellular traps' implication in tumorigenesis.

Main Results:

  • Citrullination influences apoptosis and differentiation in cancer cells.
  • Citrullination promotes epithelial-mesenchymal transition (EMT) and metastasis.
  • Citrullinated antigens show potential for cancer immunotherapy.
  • Citrullination serves as a potential cancer biomarker.
  • Neutrophil extracellular traps contribute to tumorigenesis through citrullination.

Conclusions:

  • Arginine deimination is significantly involved in multiple facets of tumor biology.
  • Further basic and translational studies are necessary to fully understand and leverage citrullination in cancer.
  • Citrullination represents a promising target for cancer diagnostics and therapeutics.

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