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Updated: Jan 27, 2026

Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
Conservative treatment of immature teeth with apical periodontitis using triple antibiotic paste disinfection
Hsin-Ju Wang1, Yea-Huey Melody Chen2, Kuan-Liang Chen2
1Department of Endodontics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, Taiwan, ROC.
Abstract:
The purpose of this report is to present conservative treatment for two immature premolars with apical periodontitis. A triple antibiotic paste was used to disinfect the root canal systems for revascularization. In both cases, residual vital pulp tissue was noted in the root canal system after the opening of each premolar. The canals in both cases were irrigated with copious sodium hypochlorite solution and medicated with a paste consisting of ciprofloxacin, metronidazole, and minocycline. The teeth were sealed with mineral trioxide aggregate and restored with composite resin. There were satisfactory outcomes after 18 months. The patients were asymptomatic, with radiographic evidence of complete resolution of radiolucency, continual thickening of dentinal walls, apical closure, and increased root length.
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