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The correlation between AMH assays differs depending on actual AMH levels.

Å Magnusson1,2, G Oleröd3, A Thurin-Kjellberg1,2

  • 1Department of Obstetrics, Gynaecology and Reproductive Medicine, Sahlgrenska University Hospital, SE-413 45 Gothenburg, Sweden.

Human Reproduction Open
|March 22, 2019
PubMed
Summary
This summary is machine-generated.

Serum anti-Müllerian hormone (AMH) levels differ significantly between laboratory assays, especially at low values. This impacts ovarian reserve assessment and fertility treatment decisions, highlighting the need for assay standardization.

Keywords:
anti-Müllerian hormoneassaycomparison

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Area of Science:

  • Reproductive endocrinology
  • Clinical chemistry
  • Biomarker validation

Background:

  • Anti-Müllerian hormone (AMH) is a key biomarker for ovarian response and fertility treatment decisions.
  • Variations in AMH assays, reference values, and sample stability complicate clinical interpretation.
  • Standardization is crucial for reliable AMH assessment in clinical practice.

Purpose of the Study:

  • To evaluate the correlation of serum AMH levels between two commonly used laboratory assays.
  • To identify potential discrepancies in AMH measurements that could affect clinical decisions.

Main Methods:

  • An observational study compared AMH levels in 269 serum samples from infertile women.
  • Serum AMH was analyzed using the Beckman Coulter Gen II ELISA original assay and the Modified Beckman Coulter Gen II ELISA (Premix method).
  • Samples were handled identically and analyzed in parallel using both assays.

Main Results:

  • The Premix method showed a mean of 18% higher AMH values compared to the Gen II original assay.
  • For low AMH levels, the Premix method yielded over 40% higher values.
  • Significant differences were observed, particularly impacting the interpretation of low AMH values.

Conclusions:

  • Considerable differences in serum AMH levels exist between the two assays, especially for low values.
  • These discrepancies can lead to misclassification of ovarian reserve and affect fertility counseling.
  • There is an urgent need for international standards for AMH assay interpretation to ensure clinical consistency.