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Related Concept Videos

Infertility in Males01:23

Infertility in Males

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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Infertility in Females01:28

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Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
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The Nucleosome Core Particle02:10

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Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
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Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
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Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
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Implementation is the execution of the nursing care plan developed during the planning phase.
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A protocol developing, disseminating and implementing a core outcome set for infertility.

J M N Duffy1,2, S Bhattacharya3, C Curtis4,5

  • 1Balliol College, University of Oxford, Oxford, UK.

Human Reproduction Open
|March 22, 2019
PubMed
Summary
This summary is machine-generated.

A core outcome set will standardize infertility research by ensuring consistent data collection and reporting across studies. This consensus aims to improve the comparability and reliability of infertility treatment trial results.

Keywords:
clinical practice guidelinesconsensus studycore outcome setinfertilitymodified Delphi methodrandomized controlled trialssystematic review

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Area of Science:

  • Reproductive Medicine
  • Clinical Trial Methodology
  • Health Outcomes Research

Background:

  • Infertility research utilizes diverse outcomes, hindering result comparison and synthesis.
  • Standardized outcomes are crucial for advancing infertility treatment evaluation.
  • A core outcome set will enhance consistency in data collection and reporting.

Purpose of the Study:

  • To develop and implement a core outcome set for future infertility research.
  • To ensure outcomes important to stakeholders are consistently collected and reported.
  • To improve the comparability and reliability of infertility treatment trials.

Main Methods:

  • Consensus study employing the modified Delphi method.
  • Involves diverse stakeholders: healthcare professionals, researchers, and individuals with lived experience.
  • Utilizes a literature review to identify potential outcomes, followed by Delphi rounds for consensus.

Main Results:

  • Potential core outcomes identified through comprehensive literature review.
  • Modified Delphi method used for consensus building among stakeholders.
  • Standardized definitions and measurement instruments will be established for core outcomes.

Conclusions:

  • A consensus-driven core outcome set is essential for robust infertility research.
  • Standardization will facilitate meta-analyses and evidence synthesis.
  • Implementation of the core outcome set will improve the quality and impact of infertility research.