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Post-transfusion purpura in a woman with acute myeloid leukemia
E de Kruijff1, A J van Gammeren, L Porcelijn
1Departments of 1nternal Medicine, Amphia Hospital, Breda, the Netherlands.
Abstract:
Post-transfusion purpura (PTP) is a rare, but severe transfusion reaction in which both donor and autologous platelets are sequestered due to immunization against HPA-1a antigens in HPA-1a negative recipients (HPA: human platelet antigens). We describe a patient who developed PTP during induction therapy for acute myeloid leukaemia. The pitfalls, delays in diagnosing and therapy options of this serious transfusion reaction are discussed.
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