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Decomposition Kinetics of Omethoate in Blood
1Criminal Investigation Detachment, Zibo Public Security Bureau, Zibo 255000, Shandong Province, China.
Omethoate decomposes in blood over time, with decomposition rates varying based on storage temperatures. For suspected omethoate poisoning, freezing blood samples and prompt analysis are recommended.
Area of Science:
- Analytical Chemistry
- Forensic Toxicology
- Pharmacokinetics
Background:
- Omethoate is an organophosphate pesticide.
- Understanding its stability in biological matrices like blood is crucial for toxicological analysis.
Purpose of the Study:
- To investigate the decomposition kinetics of omethoate in human blood.
- To determine the stability of omethoate under various storage conditions.
Main Methods:
- Omethoate standards were added to blank human blood at various concentrations.
- Samples were stored at -20°C, 4°C, and 20°C.
- High-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) was used for quantitative analysis over 120 days.
Main Results:
- Omethoate concentrations decreased over time in blood at all tested temperatures.
- The decomposition followed a first-order kinetic process, fitting a one-compartment open model.
- Storage temperature significantly influenced the decomposition rate.
Conclusions:
- Omethoate is unstable in human blood, with decomposition rates dependent on storage conditions.
- To ensure accurate results in suspected omethoate poisoning cases, blood samples should be frozen and analyzed promptly.
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