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Methylation-Based Age Estimation Model Construction and Its Effectiveness Evaluation.

S F Li1,2, F D Peng3, J N Wang4

  • 1School of Forensic Medicine, Shanxi Medical University, Taiyuan 030001, China.

Fa Yi Xue Za Zhi
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Summary
This summary is machine-generated.

This study identified eight age-related DNA methylation loci in Han males from northern China. A developed epigenetic clock model accurately estimates chronological age, aiding forensic investigations.

Keywords:
forensic genetics; forensic anthropology; DNA methylation; age determination; linear model; Han nationality; northern China; males

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Area of Science:

  • Forensic Science
  • Genetics
  • Epigenetics

Background:

  • Accurate age estimation is crucial in forensic science.
  • DNA methylation patterns exhibit age-related changes.
  • Previous age estimation models have limitations in specific populations.

Purpose of the Study:

  • To identify DNA methylation loci associated with age in Han males from northern China.
  • To develop and validate an epigenetic model for age estimation in this demographic.

Main Methods:

  • Screened 21 candidate DNA methylation loci.
  • Analyzed methylation levels in 476 blood samples using EpiTYPER.
  • Selected 8 age-related loci for model construction.

Main Results:

  • Developed a multivariate linear regression model (R²=0.93) with a Mean Absolute Deviation (MAD) of 2.69 years.
  • Validated the model on independent samples, achieving MADs between 3.80 and 4.68 years.
  • Identified specific CpG sites on genes including TRIM59, RASSF5, Clorf132, CSNK1D, ELOVL2, and PDE4C.

Conclusions:

  • The constructed age estimation model is effective for Han males in northern China.
  • The model has practical applications in forensic investigations for estimating the age of victims and suspects.
  • This epigenetic approach can help narrow down investigative scopes.