Related Experiment Video
Updated: Jan 27, 2026
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
Effects of cyclic parenteral nutrition on parenteral nutrition-associated cholestasis in newborns
Hye Jung Bae1,2, Seung Han Shin3, Ee-Kyung Kim3
1College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University, Seoul, Republic of Korea.
Insights
Cyclic parenteral nutrition (PN) helps prevent and treat PN-associated cholestasis (PNAC) in newborns. This method is safe and reduces PNAC incidence without increasing hypoglycemia or hospital stay.
Area of Science:
- Neonatal intensive care
- Pediatric gastroenterology
- Nutritional support
Background:
- Long-term parenteral nutrition (PN) can lead to PN-associated cholestasis (PNAC) in newborns.
- PNAC is a significant complication in neonates requiring extended nutritional support.
Purpose of the Study:
- To evaluate the efficacy of cyclic PN in preventing and improving PNAC in newborns.
- To assess the safety of cyclic PN regarding hypoglycemia and hospital stay.
Main Methods:
- Retrospective cohort study of 124 neonates receiving PN for over 14 days.
- Comparison of PNAC incidence between continuous PN and cyclic PN.
- Analysis of direct bilirubin levels, hypoglycemia, and length of hospital stay.
Main Results:
- PNAC incidence was 31.5% overall, with lower rates during cyclic PN periods (20.8%) compared to continuous PN (27.4%).
- Cyclic PN significantly reduced PNAC incidence (OR=0.154, p=0.003).
- Therapeutic cyclic PN decreased direct bilirubin levels; prophylactic cyclic PN maintained normal levels. No significant differences in hypoglycemia or hospital stay were found.
Conclusions:
- Cyclic PN is effective for preventing and improving PNAC in newborns.
- Cyclic PN is a safe nutritional strategy, not associated with increased hypoglycemia or prolonged hospital stay.
Background And Objectives:
Parenteral nutrition (PN) is one of the main nutritional methods used in newborns; however, long-term PN may induce PN-associated cholestasis (PNAC). This study aims to evaluate the effect of cyclic PN in the prevention and improvement of PNAC in newborns requiring long-term PN.
Methods And Study Design:
A retrospective cohort study was conducted on patients admitted at the Seoul National University Children's Hospital neonatal intensive care unit between October 2010 and September 2015 and referred to the nutrition support team with total parenteral nutrition for more than 14 days. The primary outcome was the incidence of PNAC. The incidence of hypoglycemia, changes in direct bilirubin (DB) concentrations, and length of hospital stay were investigated.
Results:
A total of 124 patients were observed in this study. Among these, 100 patients received continuous PN, whereas 24 patients received both continuous and cyclic PN. PNAC occurred in 31.5% (39/124) of study population. The incidence rates of PNAC were 27.4% during continuous PN period and 20.8% during cyclic PN period. Cyclic PN was an independent factor that significantly decreased PNAC incidence (OR=0.154; 95% CI, 0.045-0.529, p=0.003). DB concentrations significantly decreased (p=0.049) with therapeutic cyclic PN, but remained normal with prophylactic cyclic PN. No significant difference in hypoglycemia incidence and length of hospital stay was observed in both continuous PN and continuous to cyclic PN groups.
Conclusions:
Cyclic PN could be effective in the prevention and improvement of PNAC and also safe in terms of hypoglycemia in newborns.
More Related Videos
06:19Author Spotlight: Implications of Non-Nutritive Sucking on Speech Emergence and Infant Development
Published on: April 19, 2024
08:58Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
Related Concept Videos
02:11The Roles of Bacteria and Fungi in Plant Nutrition
01:24Parenteral Anesthetics: Overview
01:29Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
01:25Routes of Drug Administration: Parenteral
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
01:27Parentral Nutrition: Centeral and Peripheral Parental Nutrition
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
01:28Microbial Nutrition