Related Experiment Video
Updated: Jan 27, 2026
05:10
Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
10.2K
Identifying Drug Repurposing Opportunities in Oncology
Stefania Orecchioni1, Stefania Roma1, Sara Raimondi2
1From the Laboratory of Hematology-Oncology and.
Cancer Journal (Sudbury, Mass.)
|March 22, 2019
Summary
The high cost of new cancer drugs limits access to effective treatments and hinders clinical trials. Drug repurposing offers a cheaper, faster, and safer alternative for developing novel anticancer therapies.
Area of Science:
- Oncology
- Pharmacology
- Drug Discovery
Background:
- Rising costs of novel oncology drugs restrict patient access to advanced cancer therapies.
- High drug prices impede the development and execution of combinatorial clinical trials.
Purpose of the Study:
- To review recent advancements and challenges in drug repurposing for oncology.
- To explore the potential of using existing approved drugs for new anticancer applications.
Main Methods:
- In silico, preclinical, and clinical repurposing strategies are discussed.
- The review synthesizes current research on drug repurposing in cancer treatment.
Main Results:
- Drug repurposing presents a viable strategy to overcome cost barriers in cancer therapy.
- Approved anticancer and nonanticancer drugs can be repurposed, offering faster and safer validation.
Conclusions:
- Drug repurposing is a promising approach to enhance access to effective cancer treatments.
- Further research and development in drug repurposing are crucial for future oncology drug discovery.
Related Concept Videos
01:14Identifying Statistically Significant Differences: The F-Test
3.7K
The F-test is used to compare two sample variances to each other or compare the sample variance to the population variance. It is used to decide whether an indeterminate error can explain the difference in their values. The underlying assumptions that allow the use of the F-test include the data set or sets are normally distributed, and the data sets are independent of each other. The test statistic F is calculated by dividing one variance by another. In other words, the square of one standard...
3.7K
01:25Pharmacokinetics: Drug–Drug Interactions
428
Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
428
01:09Bioequivalence of Drugs: Drugs with Multiple Indications
156
The concept of therapeutic equivalence (TE) in drugs with multiple indications is complex. A generic drug may be therapeutically equivalent to a brand-name product for one specific indication, but this doesn't necessarily mean it's equivalent for all other indications. Evidence of TE in one patient group and bioequivalence shown in healthy volunteers can support—but not confirm—TE for other indications. However, definitive proof requires individual clinical studies for each...
156
01:26FDA Approved Drugs: Changes to Approved Drugs
256
Post-approval, manufacturers may modify an approved new or generic drug product. Such modifications can encompass alterations in the Active Pharmaceutical Ingredient (API), manufacturing process, formulation, batch size, manufacturing site, and container closure system (FDA Guidance for Industry, April 2004). Often, a drug product may undergo multiple changes.These modifications require careful evaluation to determine their potential impact on the drug product's identity, strength, quality,...
256
01:27Factors Influencing Drug Absorption: Drug Dissolution
1.2K
The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
1.2K
01:18Factors Affecting Protein-Drug Binding: Drug-Related Factors
474
Drug binding to proteins is a complex phenomenon influenced by various drug-related factors, each playing a significant role in the interaction between drugs and proteins within the body.
One crucial factor in drug-protein binding is the drug's lipophilicity or its affinity for fat. More lipophilic drugs tend to have higher binding extents. For example, highly lipophilic drugs like cloxacillin exhibit substantial protein binding, with as much as 95% of the drug binding to proteins. In...
One crucial factor in drug-protein binding is the drug's lipophilicity or its affinity for fat. More lipophilic drugs tend to have higher binding extents. For example, highly lipophilic drugs like cloxacillin exhibit substantial protein binding, with as much as 95% of the drug binding to proteins. In...
474