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3D Printing of Biomolecular Models for Research and Pedagogy
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Student Understanding of DNA Structure-Function Relationships Improves from Using 3D Learning Modules with Dynamic 3D

Michelle E Howell1,2, Christine S Booth1, Sharmin M Sikich3

  • 1Department of Biochemistry, University of Nebraska, Lincoln, Nebraska, 68588-0664.

Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology
|March 22, 2019
PubMed
Summary
This summary is machine-generated.

Interactive 3D printed molecular models enhance biochemistry education by improving student understanding of structure-function relationships. These novel learning modules offer a cost-effective way to visualize complex biomolecular structures.

Keywords:
3D printingDNARNAmodel-based learningmolecular visualizationnucleic acid structure and functionstudent misconceptions

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Area of Science:

  • Biochemistry Education
  • Molecular Biology
  • Instructional Design

Background:

  • Understanding molecular structure-function relationships is crucial in undergraduate life sciences.
  • Traditional physical models are underutilized in biochemistry classrooms.
  • 3D printing offers a cost-effective method for creating molecular models.

Purpose of the Study:

  • To develop and evaluate interactive learning modules using 3D printed models for biochemistry students.
  • To address specific student misconceptions regarding DNA and RNA structure, transcription factor-DNA interactions, and DNA supercoiling.
  • To assess the impact of these modules on student learning and visualization skills.

Main Methods:

  • Development of three interactive learning modules featuring dynamic 3D printed biomolecular models.
  • Targeting specific learning objectives related to nucleic acid structure and dynamics.
  • Creation of accompanying assessments to measure student learning gains.

Main Results:

  • Students showed normalized learning gains of 49% in understanding molecular structure-function relationships.
  • Students responded favorably to the interactive 3D printed model modules.
  • The modules effectively aided in visualizing biomolecular structures and addressing misconceptions.

Conclusions:

  • Interactive 3D printed models represent a novel and effective instructional design for biomolecular visualization in biochemistry.
  • These modules provide a practical, cost-effective approach to enhance student comprehension of complex molecular concepts.
  • The study offers instructors resources to implement these modules in their classrooms.