Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Brain Waves01:23

Brain Waves

4.1K
Brain waves are electrical signals generated by the neurons in the brain, which are regularly monitored to measure mental activities. Brain waves and their frequency ranges can be measured using an electroencephalogram or EEG. There are four main types of brain waves, each with distinct characteristics:
4.1K
Organization of the Brain01:30

Organization of the Brain

2.6K
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
2.6K
Brain Imaging01:14

Brain Imaging

724
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
724
Anatomy of the Brain: Ventricles01:18

Anatomy of the Brain: Ventricles

8.6K
There are hollow fluid-filled cavities known as ventricles deep inside the human brain. There are two lateral ventricles, one in each cerebral hemisphere, and each has three different projections — the anterior, inferior, and posterior horns visible from the lateral side. A thin membrane called the septum pellucidum separates the two lateral ventricles. The slender third ventricle in the diencephalon is connected to each lateral ventricle via a channel called the interventricular foramen.
8.6K
The Blood-brain Barrier00:49

The Blood-brain Barrier

52.7K
Overview
52.7K
Neurons as Communicators of the Brain01:22

Neurons as Communicators of the Brain

3.1K
Neurons, the fundamental units of the brain and nervous system, function as the primary transmitters of information throughout the body. Their ability to communicate through electrical and chemical signals is vital for every bodily function, from regulating the heartbeat to processing complex thoughts. Each neuron has three main components: the cell body (soma), dendrites, and an axon, each specialized to facilitate swift and efficient neural communication.
Cell Body
The cell body, also known...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond Fibrinolysis: Urokinase Plasminogen Activator as an Early Regulator of Obesity.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same author

Aquaporin-4 and caveolin-1 as mediators of fibrinogen-driven cerebrovascular pathology in cerebral amyloid angiopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Pathological mechanisms of motor dysfunction in familial Danish dementia: insights from a knock-in rat model.

Journal of neuroinflammation·2025
Same author

An antibody targeting high-molecular-weight kininogen blocks contact system activation in a model of polymicrobial sepsis.

Journal of thrombosis and haemostasis : JTH·2025
Same author

Synergistic effects of the Aβ/fibrinogen complex on synaptotoxicity, neuroinflammation, and blood-brain barrier damage in Alzheimer's disease models.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

The interaction of tPA with NMDAR1 drives neuroinflammation and neurodegeneration in α-synuclein-mediated neurotoxicity.

Journal of neuroinflammation·2025
Same journal

Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses.

Neuron·2026
Same journal

Sparse component analysis: A method that uncovers separable computations within neural population activity.

Neuron·2026
Same journal

Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens.

Neuron·2026
Same journal

TGF-β1-induced endothelial transcytosis drives blood-brain barrier leakage during aging.

Neuron·2026
Same journal

Image space opens up for visual neuroscience.

Neuron·2026
Same journal

Septal GLP-1 receptors control alcohol taking and seeking.

Neuron·2026
See all related articles

Related Experiment Video

Updated: Jan 27, 2026

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis
11:28

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis

Published on: March 25, 2016

11.3K

Inflaming the Brain.

Hyung Jin Ahn1, Sarah K Baker2, Erin H Norris2

  • 1Department of Pharmacology, Physiology and Neurosciences, Rutgers-New Jersey Medical School, Newark, NJ 07103, USA; Brain Health Institute, Rutgers University, Piscataway, NJ 08854, USA.

Neuron
|March 22, 2019
PubMed
Summary
This summary is machine-generated.

Blood-derived fibrinogen causes cognitive deficits and dendritic spine loss in Alzheimer's disease (AD) by activating microglial CD11b/CD18. This finding suggests fibrinogen is a key factor in AD pathogenesis.

More Related Videos

Determining heat and mechanical pain threshold in inflamed skin of human subjects
13:21

Determining heat and mechanical pain threshold in inflamed skin of human subjects

Published on: January 14, 2009

21.3K
Isolation of Brain and Spinal Cord Mononuclear Cells Using Percoll Gradients
09:58

Isolation of Brain and Spinal Cord Mononuclear Cells Using Percoll Gradients

Published on: February 2, 2011

42.2K

Related Experiment Videos

Last Updated: Jan 27, 2026

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis
11:28

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis

Published on: March 25, 2016

11.3K
Determining heat and mechanical pain threshold in inflamed skin of human subjects
13:21

Determining heat and mechanical pain threshold in inflamed skin of human subjects

Published on: January 14, 2009

21.3K
Isolation of Brain and Spinal Cord Mononuclear Cells Using Percoll Gradients
09:58

Isolation of Brain and Spinal Cord Mononuclear Cells Using Percoll Gradients

Published on: February 2, 2011

42.2K

Area of Science:

  • Neuroscience
  • Cerebrovascular Biology
  • Immunology

Background:

  • The precise role of cerebrovascular changes in Alzheimer's disease (AD) pathogenesis remains unclear.
  • Understanding the molecular mechanisms linking vascular factors to neurodegeneration is crucial for developing effective AD therapies.

Purpose of the Study:

  • To investigate the contribution of blood-derived fibrinogen to cognitive deficits in Alzheimer's disease.
  • To elucidate the cellular and molecular pathways through which fibrinogen impacts neuronal integrity and brain function.

Main Methods:

  • The study by Merlini et al. (2019) examined the effects of fibrinogen on neuronal structures and cognitive performance.
  • Investigated the role of microglial CD11b/CD18 in mediating fibrinogen-induced pathology.

Main Results:

  • Fibrinogen, a protein originating from the blood, was found to induce the elimination of dendritic spines, which are critical for synaptic function.
  • This fibrinogen-induced dendritic spine loss was associated with significant cognitive deficits.
  • The mechanism involves the activation of microglial CD11b/CD18 by fibrinogen.

Conclusions:

  • Blood-derived fibrinogen is implicated as a significant contributor to Alzheimer's disease pathogenesis.
  • Targeting fibrinogen or its interaction with microglial CD11b/CD18 may offer a novel therapeutic strategy for AD.