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[Association between plasma microRNA-29a and left ventricular hypertrophy in patients with hypertension]

S Y Yao1, J Liu1, Y Li1

  • 1Department of Cardiology, People's Liberition Army General Hospital, Beijing 100853, China.

Zhonghua Xin Xue Guan Bing Za Zhi
|March 23, 2019
PubMed

Insights

Plasma microRNA-29a (miRNA-29a) is elevated in hypertensive patients with left ventricular hypertrophy (LVH). This finding suggests miRNA-29a may serve as a potential biomarker for assessing LVH in hypertension.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Biomarkers

Background:

  • Plasma microRNA-29a (miRNA-29a) is linked to myocardial fibrosis and cardiac hypertrophy in hypertrophic cardiomyopathy.
  • The association between plasma miRNA-29a and hypertensive left ventricular hypertrophy (LVH) remains uninvestigated.

Purpose of the Study:

  • To investigate the relationship between plasma miRNA-29a levels and LVH in hypertensive patients.

Main Methods:

  • 168 hypertensive patients were classified into LVH (n=41) and non-LVH (NLVH, n=127) groups.
  • Echocardiography was used to assess left ventricular mass index (LVMI), interventricular septal thickness (IVSd), and left ventricular posterior wall thickness (LVPWTd).
  • Plasma miRNA-29a levels were quantified using quantitative real-time polymerase chain reaction (qRT-PCR).

Main Results:

  • Plasma miRNA-29a levels were significantly higher in the LVH group compared to the NLVH group (0.52±0.10 vs. 0.37±0.07, P<0.01).
  • Positive correlations were observed between plasma miRNA-29a levels and IVSd (R=0.459, P<0.01), LVPWTd (R=0.398, P<0.01), and LVMI (R=0.745, P<0.01).
  • Multiple regression analysis confirmed positive correlations between plasma miRNA-29a and IVSd (β=0.535, P<0.01), LVPWTd (β=0.085, P<0.01), and LVMI (β=0.806, P<0.01) after adjustments.

Conclusions:

  • Plasma miRNA-29a levels are positively associated with LVH in hypertensive patients.
  • Further research is needed to determine if miRNA-29a can be utilized as a biomarker for LVH assessment in hypertensive individuals.
Keywords:
HypertensionLeft ventricular hypertrophyMicroRNAs

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