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Redox lipidomics to better understand brain aging and function.

Reinald Pamplona1, Consuelo Borras2, Mariona Jové1

  • 1Department of Experimental Medicine, University of Lleida-Institute for Research in Biomedicine of Lleida (UdL-IRBLleida), Lleida, Spain.

Free Radical Biology & Medicine
|March 23, 2019
PubMed
Summary
This summary is machine-generated.

Lipids play a crucial role in human prefrontal cortex (PFC) aging. Lipoxidation damage to proteins in the PFC may contribute to age-related cognitive decline.

Keywords:
Advanced lipoxidation end productsAgingEnergy metabolismLipidomicsMitochondrionNeurotransmissionOxidative stressPrefrontal cortexProteostasisReactive carbonyl species

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Area of Science:

  • Neuroscience
  • Lipidomics
  • Aging Research

Background:

  • The human prefrontal cortex (PFC) is vital for cognitive functions and undergoes decline with aging.
  • Molecular mechanisms underlying PFC neuron preservation or deterioration during aging remain largely unknown.
  • The PFC exhibits a unique lipid profile due to accelerated lipid concentration evolution in humans.

Purpose of the Study:

  • To review the role of lipids in human prefrontal cortex (PFC) aging.
  • To explore the relationship between lipids, lipoxidative damage, and PFC function during aging.
  • To discuss potential interventions targeting lipid-related mechanisms in PFC aging.

Main Methods:

  • Literature review focusing on lipids, lipoxidative damage, and PFC aging.
  • Analysis of the PFC lipidome and its specific profile in human evolution.
  • Discussion of biological processes affected by lipoxidative damage in the PFC.

Main Results:

  • Lipids are central to PFC aging, with a unique lipidome shaped by human evolution.
  • Lipoxidative damage selectively targets proteins within the PFC.
  • This damage affects key biological processes, potentially leading to cognitive decline.

Conclusions:

  • Selective protein lipoxidation damage in the PFC is proposed as a mechanism for age-related cognitive decline.
  • Understanding lipid roles and lipoxidation is crucial for addressing PFC aging.
  • Interventions targeting these lipid-related processes may offer therapeutic potential.