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Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

12.6K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
12.6K
Inflammation: Introduction01:28

Inflammation: Introduction

84
Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
84
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

51
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
51
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

79
Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows...
79
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

61
Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal...
61
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

75
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Related Experiment Video

Updated: May 6, 2026

Isolation and Flow Cytometric Characterization of Murine Small Intestinal Lymphocytes
08:14

Isolation and Flow Cytometric Characterization of Murine Small Intestinal Lymphocytes

Published on: May 8, 2016

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Intestinal immunity and inflammation: recent progress.

C O Elson, M F Kagnoff, C Fiocchi

    Gastroenterology
    |September 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Researchers are defining intestinal lymphoid cells and their functions. Advances in technology are aiding the study of mucosal immunology and chronic inflammatory diseases of the intestine.

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    Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
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    Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
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    Related Experiment Videos

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    Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
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    Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
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    Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

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    Area of Science:

    • Mucosal immunology
    • Intestinal immune microenvironment

    Background:

    • Defining the specific lymphoid cell populations within the intestine.
    • Understanding the unique sets of lymphoid cells present only in the intestine.
    • Elucidating the functional roles of intestinal lymphoid cells within their microenvironment.

    Purpose of the Study:

    • To understand how intestinal lymphoid cell populations communicate and regulate each other.
    • To explore the role of cell surface molecules (e.g., MHC class I and II) and soluble mediators in intestinal immunity.
    • To leverage technological advancements to answer fundamental questions in mucosal immunology and chronic intestinal inflammatory diseases.

    Main Methods:

    • Utilizing recent technological advancements in immunology.
    • Investigating cell-cell communication via surface molecules.
    • Analyzing the role of soluble mediators (lymphokines) in immune regulation.

    Main Results:

    • Technological advances provide tools to address key questions in mucosal immunology.
    • Understanding immune regulation in the intestine is crucial for comprehending inflammatory diseases.
    • The mechanisms controlling the immune system's destructive potential in the gut are not fully understood.

    Conclusions:

    • Ongoing research is defining intestinal lymphoid cell sets and their functions.
    • Technological progress is accelerating discoveries in mucosal immunology.
    • Insights into intestinal immune regulation may unlock new understanding of chronic inflammatory diseases.