Related Experiment Video
Updated: Jan 27, 2026
15:01
Tracking Neutrophil Intraluminal Crawling, Transendothelial Migration and Chemotaxis in Tissue by Intravital Video Microscopy
Published on: September 24, 2011
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Neutrophil transendothelial migration: updates and new perspectives
1Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Research Foundation, Cincinnati, OH; and University of Cincinnati College of Medicine, Cincinnati, OH.
Blood
|March 23, 2019
Summary
Neutrophils, the first responders to infection, migrate through blood vessel walls. Their transmigration process, either between or through endothelial cells, is adaptable and context-dependent, offering clinical potential.
Area of Science:
- Immunology
- Cell Biology
- Vascular Biology
Background:
- Neutrophils are critical immune cells acting as the first line of defense against pathogens.
- Neutrophil recruitment involves a cascade of adhesion and migration events across the blood-endothelial cell (EC) barrier.
- Neutrophil transmigration can occur paracellularly (between ECs) or transcellularly (through ECs).
Purpose of the Study:
- To review recent advances in understanding neutrophil transmigration mechanisms.
- To explore the plasticity of neutrophil functions and transmigration modes.
- To discuss the clinical implications of neutrophil-EC interactions and transmigration plasticity.
Main Methods:
- Literature review of recent research on neutrophil transmigration.
- Analysis of molecular interactions between neutrophils and endothelial cells.
- Discussion of context-dependent factors influencing diapedesis pathways.
Main Results:
- Neutrophil transmigration is not a fixed process but exhibits significant plasticity.
- The mode of diapedesis (paracellular vs. transcellular) is influenced by specific neutrophil-EC interactions and the microenvironment.
- Recent findings highlight the dynamic nature of neutrophil functions during extravasation.
Conclusions:
- Neutrophil transmigration is a highly regulated and adaptable process.
- Understanding the plasticity of neutrophil diapedesis offers potential therapeutic targets.
- Exploiting neutrophil functional plasticity may lead to novel clinical strategies for inflammatory diseases.
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