Related Experiment Video

Updated: Jan 27, 2026

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
06:19

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

4.5K

Lactobacillus reuteri Reduces the Severity of Experimental Autoimmune Encephalomyelitis in Mice by Modulating Gut

Baokun He1, Thomas K Hoang1, Xiangjun Tian2

  • 1Division of Gastroenterology, Departments of Pediatrics, The University of Texas Health Science Center at Houston-McGovern Medical School, Houston, TX, United States.

Frontiers in Immunology
|March 23, 2019
PubMed

Insights

Probiotic Lactobacillus reuteri (L. reuteri) eased multiple sclerosis symptoms in a mouse model by reducing harmful immune cells and restoring gut bacteria diversity. This suggests L. reuteri may help manage MS severity.

Area of Science:

  • Immunology
  • Microbiology
  • Neuroscience

Background:

  • The gut microbiome influences immune function and is linked to multiple sclerosis (MS).
  • The potential of microbiota modulation for MS prevention or treatment is largely unexplored.

Purpose of the Study:

  • To investigate the therapeutic potential of probiotic Lactobacillus reuteri (L. reuteri) in experimental autoimmune encephalomyelitis (EAE), an animal model of MS.
  • To determine the effects of L. reuteri on immune cell populations and gut microbiota composition in EAE.

Main Methods:

  • Administration of L. reuteri DSM 17938 to mice with EAE.
  • Assessment of T helper 1 (TH1) and T helper 17 (TH17) cell populations and their associated cytokines (IFN-γ, IL-17).
  • Analysis of gut microbiota diversity and composition using 16S rRNA sequencing.

Main Results:

  • L. reuteri treatment ameliorated EAE development and reduced TH1/TH17 cell responses and associated cytokines.
  • EAE-induced loss of gut microbiota diversity was restored by L. reuteri treatment.
  • Specific bacterial genera (Bifidobacterium, Prevotella, Lactobacillus) were negatively correlated with EAE severity, while others (Anaeroplasma, Rikenellaceae, Clostridium) were positively correlated. L. reuteri modulated these taxa.

Conclusions:

  • Probiotic L. reuteri modulates gut microbiota and immune responses in the EAE model.
  • L. reuteri demonstrates potential as a therapeutic candidate for modifying MS severity.
Keywords:
IFN-γ/IL-17Lactobacillus reuteriTH1/TH17 cellsexperimental autoimmune encephalomyelitisgut microbiota

More Related Videos

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice07:54

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice

Published on: July 25, 2017

14.7K
Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis08:17

Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis

Published on: February 23, 2024

5.6K

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
1.6K
Reducing Line Loss01:18

Reducing Line Loss

In a three-phase circuit, line loss is an indicator of energy dissipated as heat due to the resistance of transmission lines. To address this, incorporating transformers into the system—a step-up transformer at the source and a step-down transformer at the load—is a strategic solution. Two three-phase transformers are introduced to improve this.
With a step-up transformer at the source, the voltage is increased, thereby reducing the current in the transmission lines since power loss in...
372
Methods of reducing fever01:22

Methods of reducing fever

The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
1.3K
Adaptations that Reduce Water Loss01:57

Adaptations that Reduce Water Loss

Though evaporation from plant leaves drives transpiration, it also results in loss of water. Because water is critical for photosynthetic reactions and other cellular processes, evolutionary pressures on plants in different environments have driven the acquisition of adaptations that reduce water loss.
28.0K
Role of Reduced Coenzymes NADH and FADH₂01:29

Role of Reduced Coenzymes NADH and FADH₂

The energy released from the breakdown of the chemical bonds within nutrients can be stored either through the reduction of electron carriers or in the bonds of adenosine triphosphate (ATP). In living systems, a small class of compounds functions as mobile electron carriers, molecules that bind to and shuttle high-energy electrons between compounds in pathways. The principal electron carriers that will be considered originate from the B vitamin group and are derivatives of nucleotides; they are...
16.4K
Redox Titration: Other Oxidizing and Reducing Agents01:26

Redox Titration: Other Oxidizing and Reducing Agents

Besides iodine, other oxidizing or reducing agents can serve as titrants in redox titrations. Common oxidizing titrants include KMnO4, cerium(IV), and K2Cr2O7. The choice of oxidizing titrants depends on factors like stability, cost, analyte strength, and reaction rate between the analyte and titrant. KMnO4 is a strong oxidizing titrant that reduces from Mn(VII) to Mn(II) in a highly acidic solution, simultaneously oxidizing the analyte to a higher oxidation state. In this case, KMnO4 acts as a...
1.4K