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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

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Identification of key proteins and lncRNAs in hypertrophic cardiomyopathy by integrated network analysis

Xiaofeng Hu1, Guilin Shen2, Xiaoli Lu2

  • 1Department of Cardiology, Zhejiang Hospital, Hangzhou, Zhejiang Province, China.

Archives of Medical Science : AMS
|March 23, 2019
PubMed

Insights

This study identified key long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) dysregulated in hypertrophic cardiomyopathy (HCM). These findings shed light on molecular mechanisms and potential biomarkers for HCM diagnosis.

Area of Science:

  • Genomics
  • Molecular Biology
  • Cardiovascular Research

Background:

  • Hypertrophic cardiomyopathy (HCM) is a genetic heart disorder causing sudden cardiac death in young individuals.
  • The precise molecular mechanisms driving HCM progression remain largely unknown.
  • Non-coding RNAs are increasingly recognized for their roles in human disease pathogenesis.

Purpose of the Study:

  • To identify differentially expressed long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) in hypertrophic cardiomyopathy (HCM).
  • To analyze the molecular pathways and interactions associated with these dysregulated genes in HCM.
  • To uncover potential molecular targets and biomarkers for HCM.

Main Methods:

  • Bioinformatics analysis of a public dataset (GSE36961) for HCM.
  • Gene Ontology (GO) analysis to assess the functions of differentially expressed genes and lncRNAs.
  • Construction of protein-protein interaction (PPI) and co-expression networks to identify key lncRNAs and their interactions.

Main Results:

  • Identified 6147 differentially expressed mRNAs and 126 dysregulated lncRNAs in HCM.
  • GO analysis revealed associations with metabolism, energy pathways, signal transduction, and cell communication.
  • Key lncRNAs including TSPYL3, LOC401431, LOC158376, LOC606724, PDIA3P, and LOH3CR2A were identified as crucial in HCM progression.

Conclusions:

  • The study identified specific lncRNAs and mRNAs involved in HCM progression through regulatory pathways.
  • These findings offer insights into the molecular mechanisms underlying HCM.
  • The identified molecules represent potential candidate biomarkers for HCM diagnosis and therapeutic strategies.
Abstract

Keywords:
co-expression analysisdifferentially expressed genehypertrophic cardiomyopathylong non-coding RNAprotein-protein interaction analysis

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