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Niclosamide ethanolamine protects kidney in adriamycin nephropathy by regulating mitochondrial redox balance

Pengxun Han1, Changjian Yuan1, Yao Wang1

  • 1Department of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine Shenzhen, Guangdong, China.

American Journal of Translational Research
|March 23, 2019
PubMed

Insights

Niclosamide ethanolamine salt (NEN) offers kidney protection in non-diabetic kidney disease by reducing protein and hydrogen peroxide excretion. This mitochondrial uncoupler also improves renal pathology and biomarkers of tubular injury.

Area of Science:

  • Nephrology
  • Mitochondrial Biology
  • Oxidative Stress Research

Background:

  • Chronic kidney disease (CKD) involves proteinuria, glomerulosclerosis, and tubulointerstitial fibrosis.
  • Mitochondrial dysfunction and reactive oxygen species (ROS) overproduction are key in CKD pathogenesis.
  • Mitochondrial uncoupling regulates mitochondrial function and ROS production.

Purpose of the Study:

  • To investigate the renoprotective effects of Niclosamide ethanolamine salt (NEN) in non-diabetic kidney disease.
  • To determine NEN's impact on proteinuria, podocyte function, renal pathology, and tubular injury biomarkers.
  • To elucidate the mechanisms underlying NEN's effects on mitochondrial function and redox balance.

Main Methods:

  • Adriamycin-induced non-diabetic kidney disease model in mice.
  • Assessment of urinary protein excretion and tubular injury biomarkers (NGAL, Kim-1).
  • Evaluation of kidney mitochondrial function, hydrogen peroxide (H2O2) production and excretion, and expression of catalase and PGC-1α.

Main Results:

  • NEN significantly reduced urinary protein excretion and ameliorated renal pathological injury.
  • NEN restored podocyte function and decreased urinary excretion of NGAL and Kim-1.
  • NEN uncoupled kidney mitochondria, dose-dependently decreased renal H2O2 production and excretion, and increased catalase and PGC-1α expression.

Conclusions:

  • NEN demonstrates significant renoprotective effects in adriamycin-induced non-diabetic kidney disease.
  • NEN protects the kidney by regulating redox balance, decreasing oxidative stress, and improving mitochondrial function.
  • These findings highlight NEN as a potential therapeutic agent for non-diabetic kidney diseases.
Keywords:
Niclosamide ethanolamine saltadriamycin nephropathymitochondriaredox balance

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