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Autonomic maturation from birth to 2 years: normative values.
Hugues Patural1,2, Vincent Pichot2, Sophie Flori2
1Neonatal Intensive Care Unit, Pediatric Department, University Hospital of Saint-Etienne, France.
Heliyon
|March 23, 2019
Summary
This study tracked heart rate variability (HRV) in healthy newborns for two years. Findings reveal a shift towards parasympathetic dominance, indicating normal autonomic nervous system maturation.
Area of Science:
- Neonatal Physiology
- Autonomic Nervous System Development
- Cardiovascular Regulation
Background:
- Heart rate variability (HRV) is a key non-invasive indicator of autonomic nervous system (ANS) function.
- Limited data exists on autonomic control maturation in early infancy.
- The Autonomic Baby Evaluation (AuBE) cohort established normal autonomic maturation profiles from birth to 2 years in healthy newborns.
Purpose of the Study:
- To establish normative data for autonomic maturation in healthy full-term newborns.
- To characterize the development of heart rate control during the first two years of life.
- To provide a reference for assessing autonomic nervous system function in infancy.
Main Methods:
- Longitudinal HRV analysis in 271 full-term newborns from birth to 24 months.
- Data collected via polysomnography and 24-hour ambulatory ECG recordings.
- Utilized ANSLabTools software for comprehensive HRV index calculation.
Main Results:
- Detailed HRV indices presented across temporal, frequency, and complexity domains.
- Normative data provided at 0, 6, 12, 18, and 24 months, including percentile distributions.
- Analysis considered sex-based variability in autonomic maturation.
Conclusions:
- Established the physiological autonomic maturation profile from birth to 2 years in healthy term neonates.
- Demonstrated a progressive shift towards parasympathetic activity dominance.
- Indicated a fine-tuning of autonomic control, leading to a new equilibrium in early childhood.
Keywords:
Neuroscience
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