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Hemospray hemostasis in bleeding diffusely ulcerated esophagus.

Shou-Jiang Tang1, Pegah Hosseini-Carroll1, Telciane S Vesa1

  • 1Division of Digestive Diseases, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.

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Hemospray effectively achieved hemostasis in diffuse esophageal ulcerations, even when conventional treatments failed. This hemostatic powder offers a promising first-line therapy for significant esophageal bleeding.

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Area of Science:

  • Gastroenterology
  • Endoscopy
  • Hemostasis

Background:

  • Diffuse esophageal ulcerations present a significant challenge for hemostasis.
  • Conventional treatments like clipping and injection therapy may be insufficient for severe bleeding.
  • Hemospray, a hemostatic powder, acts by concentrating clotting factors and forming mechanical plugs.

Purpose of the Study:

  • To evaluate the efficacy of Hemospray as a first-line monotherapy for diffuse esophageal ulcerations with significant bleeding.
  • To assess the potential of Hemospray in reducing the need for repeat endoscopic procedures.
  • To explore the cytoprotective role of Hemospray in promoting ulcer healing.

Main Methods:

  • Case series of 3 patients with diffusely ulcerated esophagus and significant bleeding.
  • Initial 2 cases refractory to conventional hemostatic treatments (clipping, injection therapy).
  • Hemospray utilized as first-line monotherapy in the third case.

Main Results:

  • Immediate hemostasis achieved in all 3 patients.
  • No recurrent bleeding observed in any patient for over 2 months post-treatment.
  • Hemospray demonstrated successful control of diffuse esophageal bleeding.

Conclusions:

  • Hemospray application is proposed as a first-line therapy for diffuse esophageal ulcerations with significant bleeding.
  • This approach may decrease the requirement for repeat endoscopic interventions.
  • Hemospray forms a protective barrier, facilitating mucosal healing by shielding from acid reflux.