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Updated: Jan 27, 2026

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish
Published on: February 22, 2019
Rituximab dosing in hematological malignancies: an old question, revisited
Peter N Morcos1, Axel Boehnke2, Nancy Valente3
1Clinical Pharmacology, Pharmaceutical Sciences, Pharma Research and Early Development (pRED), Roche Innovation Center, New York, 430 East 29th Street, 10016, New York City, NY, USA. peter.morcos@roche.com.
Abstract:
Rituximab is the standard of care for most B-cell malignancies. Its rapid clinical development enabled patients to receive this life-prolonging medicine sooner; however, it precluded a thorough assessment of dose selection. Extensive clinical pharmacology data collected from the recent subcutaneous development program enabled re-examination of this old question and support that the approved rituximab dosing regimens in non-Hodgkin's lymphoma and chronic lymphocytic leukemia appear to maximize the clinical benefit in the majority of patients.
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