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The therapeutic potential of metformin in gastric cancer

Sarah Courtois1, Philippe Lehours2,3, Emilie Bessède2,3

  • 1INSERM, Univ. Bordeaux, UMR1053 Bordeaux Research In Translational Oncology, BaRITOn, 33000, Bordeaux, France. courtois.sa@gmail.com.

Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
|March 23, 2019
PubMed

Insights

Metformin, a diabetes drug, shows potential anti-cancer effects in gastric cancer. This study explores its mechanisms against gastric cancer cell lines and stem cells.

Area of Science:

  • Oncology
  • Pharmacology
  • Endocrinology

Background:

  • Metformin is a widely used biguanide medication for type 2 diabetes since 1957.
  • Epidemiological studies suggest metformin use correlates with reduced cancer incidence in diabetic patients.
  • Metformin's antitumoral properties are increasingly investigated across various cancer types since 2005.

Purpose of the Study:

  • To investigate the poorly understood antitumoral effects of metformin in gastric cancer.
  • To elucidate the mechanisms underlying metformin's potential efficacy against gastric cancer.

Main Methods:

  • Review of existing literature on metformin's antitumoral mechanisms.
  • Analysis of signaling pathways involved in metformin's action.
  • Examination of functional effects on gastric cancer cell lines and stem cells.

Main Results:

  • Detailed description of various proposed mechanisms of metformin's antitumoral action.
  • Exploration of effects on signaling pathways relevant to gastric cancer.
  • Assessment of impact on gastric cancer cell lines and stem cell populations.

Conclusions:

  • Metformin exhibits potential antitumoral effects in gastric cancer through diverse mechanisms.
  • Further research is warranted to fully understand and potentially utilize metformin in gastric cancer therapy.
  • The study highlights signaling pathways and functional effects on cancer cells and stem cells.
Keywords:
Cancer stem cellsEMTGastric adenocarcinomaTumour growth

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